细胞周期蛋白依赖性激酶5（Cdk5）与环磷酸腺苷/蛋白激酶A（cAMP/PKA）信号通路在神经精神疾病和神经退行性疾病介导过程中的相互作用

Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases.

作者信息

Hu Yafang, Pan Suyue, Zhang Han-Ting

机构信息

Department of Neurology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong, 510515, China.

Department of Behavioral Medicine and Psychiatry, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, WV, 26506, USA.

出版信息

Adv Neurobiol. 2017;17:45-61. doi: 10.1007/978-3-319-58811-7_3.

DOI:10.1007/978-3-319-58811-7_3

PMID:28956329

Abstract

Both cyclin-dependent kinase 5 (Cdk5) and cyclic AMP (cAMP)/protein kinase A (PKA) regulate fundamental central nervous system (CNS) functions including neuronal survival, neurite and axonal outgrowth, neuron development and cognition. Cdk5, a serine/threonine kinase, is activated by p35 or p39 and phosphorylates multiple signaling components of various pathways, including cAMP/PKA signaling. Here, we review the recent literature on the interaction between Cdk5 and cAMP/PKA signaling and their role in the mediation of CNS functions and neuropsychiatric and neurodegenerative diseases.

摘要

细胞周期蛋白依赖性激酶5（Cdk5）和环磷酸腺苷（cAMP）/蛋白激酶A（PKA）都调节中枢神经系统（CNS）的基本功能，包括神经元存活、神经突和轴突生长、神经元发育和认知。Cdk5是一种丝氨酸/苏氨酸激酶，由p35或p39激活，并使包括cAMP/PKA信号通路在内的各种信号通路的多个信号成分磷酸化。在此，我们综述了关于Cdk5与cAMP/PKA信号通路之间相互作用及其在介导中枢神经系统功能以及神经精神疾病和神经退行性疾病中作用的最新文献。