[α-氨基甲基酮作为膜结合丙氨酸氨基肽酶的抑制剂]
[alpha-Aminomethylketones as inhibitors of a membrane-bound alanine aminopeptidase].
作者信息
Jahreis G, Fittkau S, Aurich H
机构信息
Bereich Medizin, Martin-Luther-Universität Halle-Wittenberg, Saale.
出版信息
Biomed Biochim Acta. 1987;46(10):683-6.
PMID:2895641
Abstract
Methyl ketone derivatives of L-amino acids are substrate analogous inhibitors of membrane bound alanine aminopeptidase (EC 3.4.11.2) from Acinetobacter calcoaceticus. The type of inhibition is competitive. Compounds with a branched aliphatic side chain are most effective so that valine methyl ketone was found to be the best inhibitor of the enzyme with a K-value of 5.5.10(-7) mol.l-1.
摘要
L-氨基酸的甲基酮衍生物是醋酸钙不动杆菌膜结合丙氨酸氨肽酶（EC 3.4.11.2）的底物类似物抑制剂。抑制类型为竞争性。具有支链脂肪族侧链的化合物最有效，因此发现缬氨酸甲基酮是该酶的最佳抑制剂，其K值为5.5×10⁻⁷mol·L⁻¹。
Zotero 插件