氟哌啶醇长期治疗对大鼠多个脑区神经元活性及敏感性的影响。
The influence of long-term treatment with haloperidol on neuronal activity and sensitivity in several brain structures of the rat.
作者信息
Jähkel M, Oehler J, Schmidt J
机构信息
Institute of Pharmacology and Toxicology, Medical Academy Carl Gustav Carus, Dresden, GDR.
出版信息
Biomed Biochim Acta. 1987;46(10):735-41.
PMID:2895642
Abstract
The influence of long-term haloperidol pretreatment on neuronal spontaneous activity and transmitter sensitivity was investigated in prefrontal cortex, hippocampus and locus coeruleus. The changes are different in all areas as well as in the transmission systems involved. In particular cases, analogies exist between haloperidol- and isolation-induced changes, reflecting a comparable dopaminergic supersensitivity.
摘要
研究了长期使用氟哌啶醇预处理对前额叶皮质、海马和蓝斑中神经元自发活动及递质敏感性的影响。所有区域以及所涉及的传导系统中的变化各不相同。在特定情况下，氟哌啶醇诱导的变化与隔离诱导的变化之间存在相似性，这反映了类似的多巴胺能超敏反应。
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