Yasuda N, Lai P K, Ip S H, Kung P C, Hinuma Y, Matsuoka M, Hattori T, Takatsuki K, Purtilo D T
Department of Pathology, University of Nebraska Medical Center, Omaha.
Blood. 1988 Apr;71(4):1021-6.
Serum concentrations of soluble interleukin 2 receptors (sIL 2R) were measured by an enzyme-linked immunosorbent assay (ELISA) in 30 patients with adult T cell leukemia (ATL), in 9 patients with other hematopoietic malignancies, and in 17 asymptomatic individuals seropositive for human T cell leukemia virus type I (HTLV-I). Sixty HTLV-I seronegative, age-matched controls showed a normal range of form 63.2 to 480.8 U/mL. All asymptomatic carriers of HTLV-I had sIL 2R in their sera within the normal range. sIL 2R in sera was not related to the anti-HTLV-I antibody titer. Eleven patients with acute ATL, a clinical phenotype with median survival rate of 4.4 months, had markedly elevated sIL 2R (11,100 to 99,000 U/mL), but eight patients with smoldering ATL had low sIL 2R values (less than 480.8 U/mL) comparable to controls. Eleven patients with chronic ATL had intermediate elevated levels of sIL 2R (480.8 to 37,300.0 U/mL). Serum levels of sIL 2R correlated with the number of ATL cells (r = 0.812) and CD25-positive cells (r = 0.725) circulating in the peripheral blood. Longitudinal studies performed in four patients with ATL showed significant correlation between serum concentration of sIL 2R and activity of the malignancy. These findings suggest that the level of sIL 2R in serum indicated tumor load and, possibly, prognosis.
采用酶联免疫吸附测定法（ELISA）检测了30例成人T细胞白血病（ATL）患者、9例其他造血系统恶性肿瘤患者以及17例I型人类T细胞白血病病毒（HTLV-I）血清学阳性的无症状个体的血清可溶性白细胞介素2受体（sIL 2R）浓度。60例年龄匹配的HTLV-I血清学阴性对照者的sIL 2R浓度在63.2至480.8 U/mL的正常范围内。所有HTLV-I无症状携带者血清中的sIL 2R均在正常范围内。血清中的sIL 2R与抗HTLV-I抗体滴度无关。11例急性ATL患者（临床表型，中位生存期为4.4个月）的sIL 2R显著升高（11,100至99,000 U/mL），但8例冒烟型ATL患者的sIL 2R值较低（低于480.8 U/mL），与对照者相当。11例慢性ATL患者的sIL 2R水平中度升高（480.8至37,300.0 U/mL）。血清sIL 2R水平与外周血中循环的ATL细胞数量（r = 0.812）和CD25阳性细胞数量（r = 0.725）相关。对4例ATL患者进行的纵向研究显示，血清sIL 2R浓度与恶性肿瘤活性之间存在显著相关性。这些发现表明，血清中sIL 2R水平可指示肿瘤负荷，并可能提示预后。
