2-乙酰氨基芴通过非细胞毒性机制促进肝癌发生。
2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism.
作者信息
Saeter G, Schwarze P E, Nesland J M, Seglen P O
机构信息
Department of Tissue Culture, Norwegian Radium Hospital, Oslo.
出版信息
Carcinogenesis. 1988 Apr;9(4):581-7. doi: 10.1093/carcin/9.4.581.
2-Acetylaminofluorene (AAF), given in the diet at 0.02% for 4 weeks, is an effective promoter of liver carcinogenesis initiated by partial hepatectomy (PH) plus diethylnitrosamine (DEN) in the inbred rat strain Wistar Kyoto. AAF promotes the early (6 week) appearance of phenotypically altered (gamma-glutamyltranspeptidase-positive) cells as well as the later appearance of neoplastic nodules (2-4 months) and hepatocarcinomas (4-8 months). Promotion does not seem to involve selective cytotoxicity (selection of AAF-resistant hepatocytes), since neither AAF alone nor DEN + AAF has any inhibitory effect on overall liver growth.
在近交系大鼠Wistar Kyoto中，以0.02%的剂量在饮食中给予2-乙酰氨基芴（AAF）4周，是由部分肝切除术（PH）加二乙基亚硝胺（DEN）引发的肝癌发生的有效促进剂。AAF促进了表型改变（γ-谷氨酰转肽酶阳性）细胞的早期（6周）出现，以及肿瘤结节（2-4个月）和肝癌（4-8个月）的后期出现。促进作用似乎不涉及选择性细胞毒性（选择对AAF耐药的肝细胞），因为单独的AAF或DEN + AAF对肝脏整体生长均无任何抑制作用。
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