State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province 225009, China.
State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province 225009, China..
Int Immunopharmacol. 2017 Nov;52:253-260. doi: 10.1016/j.intimp.2017.08.028. Epub 2017 Oct 12.
Since 1985, interferon (IFN)-ω, a type I IFN, has been identified in many animals, but not canines and mice. It has been demonstrated to have antiviral, anti-proliferation, and antitumor activities that are similar to those of IFN-α. To date, IFN-ω has been explored as a treatment option for some diseases or viral infections in humans and other animals. Studies have revealed that human IFN-ω displays antitumor activities in some models of human cancer cells and that it can be used to diagnose some diseases. While recombinant feline IFN-ω has been licensed in several countries for treating canine parvovirus, feline leukemia virus, and feline immunodeficiency virus infections, it also exhibits a certain efficacy when used to treat other viral infections or diseases. This review examines the known biological activity of IFN-ω and its clinical applications. We expect that the information provided in this review will stimulate further studies of IFN-ω as a therapeutic agent.
自 1985 年以来，已在许多动物中鉴定出Ⅰ型干扰素 IFN-ω，但犬科和鼠科动物中尚未发现。研究表明，IFN-ω 具有与 IFN-α 相似的抗病毒、抗增殖和抗肿瘤活性。迄今为止，IFN-ω 已被探索用于治疗人类和其他动物的某些疾病或病毒感染。研究表明，人源 IFN-ω 在某些人类癌细胞模型中具有抗肿瘤活性，可用于诊断某些疾病。虽然重组猫源 IFN-ω 已在多个国家获得许可，用于治疗犬细小病毒、猫白血病病毒和猫免疫缺陷病毒感染，但在治疗其他病毒感染或疾病时也具有一定疗效。本综述探讨了 IFN-ω 的已知生物学活性及其临床应用。我们期望本综述提供的信息将激发对 IFN-ω 作为治疗剂的进一步研究。
