Hospital Universitari Institut Pere Mata. IISPV. Universitat Rovira i Virgili. CIBERSAM, Ctra. de l'Institut Pere Mata, s/n., Reus, 43206 Tarragona, Spain.
Universidad San Buenaventura, Faculty of Psychology, Carrera 56C No. 51-110 Office: 207-B Medellín, Antioquia, Colombia.
Psychiatry Res. 2017 Dec;258:551-556. doi: 10.1016/j.psychres.2017.09.007. Epub 2017 Sep 7.
Schizotypy has been proposed to be the expression of genetic vulnerability to schizophrenia. The available literature shows cognitive similarities between schizotypy and schizophrenia, with mildly impaired performance being associated with schizotypy. This study aims to determine the relationship between schizotypy and cognitive performance in siblings of patients with psychosis.
Schizotypal features and cognitive performance on a neuropsychological battery were compared between 48 siblings of patients with psychosis and 44 healthy controls. The relationships between schizotypy and cognitive performance were analysed by controlling the condition of being a sibling.
Siblings showed poorer performance on vigilance/sustained attention (M = 37.6; SD = 7.1) and selective attention/interference control/working memory (M = 23.28; SD = 2.7) tasks. The variance in vigilance/sustained attention performance was explained, at 30%, by the interpersonal factor of schizotypy on the suspiciousness dimension and the condition of being a sibling.
Interpersonal features of schizotypy in siblings of patients with psychosis are associated with deficits in vigilance/sustained attention performance.
分裂型特质被认为是对精神分裂症遗传易感性的表现。现有文献表明，分裂型特质与精神分裂症之间存在认知相似性，表现为轻度认知功能受损与分裂型特质相关。本研究旨在确定精神分裂症患者的兄弟姐妹中分裂型特质与认知表现之间的关系。
比较 48 名精神分裂症患者的兄弟姐妹和 44 名健康对照者的分裂型特征和神经认知测试表现。通过控制作为兄弟姐妹的条件，分析了分裂型特质与认知表现之间的关系。
兄弟姐妹在警觉/持续注意力（M = 37.6；SD = 7.1）和选择性注意力/干扰控制/工作记忆（M = 23.28；SD = 2.7）任务上表现较差。警觉/持续注意力表现的方差在 30%的程度上可以由人际关系因素中的可疑维度和作为兄弟姐妹的条件来解释。
精神分裂症患者的兄弟姐妹的人际关系特征与警觉/持续注意力表现的缺陷有关。
