HOE 760（组胺H2受体拮抗剂）对地西泮药代动力学的影响。

Effects of HOE 760 (histamine H2-receptor antagonist) on diazepam pharmacokinetics.

作者信息

Meyer B H, Müller F O, Badian M, Hundt H K, Joubert A L, Luus H G

机构信息

Department of Pharmacology, University of the Orange Free State, Bloemfontein.

出版信息

S Afr Med J. 1988 Apr 2;73(7):421-3.

PMID:2895963

Abstract

A double-blind cross-over study of the effects of HOE 760 (histamine H2-receptor blocker) on diazepam pharmacokinetics was conducted in 12 healthy men. HOE 760 or placebo was given daily for 12 days and, after a wash-out period of 9 days, the alternate medication was given for 12 days. Diazepam 10 mg was given intravenously on day 6 of each of the 12-day periods. Blood was taken up to 1 week after the diazepam injections for assay of diazepam and desmethyldiazepam. The co-administration of HOE 760 did not affect the pharmacokinetics of diazepam and desmethyldiazepam.

摘要

在12名健康男性中进行了一项关于HOE 760（组胺H2受体阻滞剂）对地西泮药代动力学影响的双盲交叉研究。每天给予HOE 760或安慰剂，持续12天，经过9天的洗脱期后，给予另一种药物，持续12天。在每个12天周期的第6天静脉注射10毫克地西泮。在地西泮注射后长达1周采集血液，用于检测地西泮和去甲基地西泮。HOE 760的联合使用不影响地西泮和去甲基地西泮的药代动力学。