Division of Geriatric Psychiatry, First Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece.
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Baltimore, MD, USA.
Int J Geriatr Psychiatry. 2018 Feb;33(2):e177-e192. doi: 10.1002/gps.4783. Epub 2017 Sep 29.
Apathy is one of the most frequent neuropsychiatric symptoms encountered in dementia. Early diagnosis and timely treatment of apathy in dementia are crucial because apathy has been associated with poor disease outcome, reduced daily functioning, and caregiver distress.
Extensive electronic search from the databases included in the National Library of Medicine as well as PsychInfo and Google Scholar for studies which have investigated the effect of non-pharmacological treatments of apathy in dementia. Quality of the studies was appraised.
A total of 1303 records were identified and 120 full-texts assessed. Forty-three unique studies were reviewed. A variety of interventions were found to be effective in reducing apathy in demented patients, particularly when provided in a multidisciplinary manner. However, quantification of the effect was limited by the marked methodological heterogeneity of the studies and the small number of studies where apathy was the primary outcome measure.
Treatment of apathy in dementia is a complex and underexplored field. Certain studies suggest promise for a variety of non-pharmacological interventions. Standardized and systematic efforts primarily focusing on apathy may establish a benefit from individualized treatments for specific disease groups.
淡漠是痴呆患者最常见的神经精神症状之一。早期诊断和及时治疗痴呆患者的淡漠至关重要，因为淡漠与不良的疾病结局、日常功能下降以及照护者的痛苦有关。
从美国国家医学图书馆的数据库、PsychInfo 和 Google Scholar 进行广泛的电子搜索，以查找研究非药物治疗痴呆患者淡漠的效果的研究。评估研究的质量。
共确定了 1303 条记录，并评估了 120 篇全文。综述了 43 项独特的研究。发现各种干预措施在减少痴呆患者的淡漠方面都有效，尤其是以多学科方式提供的干预措施。然而，由于研究的方法学异质性显著，以及将淡漠作为主要结局指标的研究数量较少，因此限制了对效果的量化。
痴呆患者的淡漠治疗是一个复杂且尚未得到充分探索的领域。某些研究表明，各种非药物干预措施有一定的前景。主要关注淡漠的标准化和系统努力可能会为特定疾病群体的个体化治疗带来益处。
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