Raza Zulfiqar Ali, Riaz Shahina, Banat Ibrahim M
Dept. of Applied Sciences, National Textile University, Faisalabad, 37610, Pakistan.
School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, U.K.
Biotechnol Prog. 2018 Jan;34(1):29-41. doi: 10.1002/btpr.2565. Epub 2017 Oct 16.
Polyhydroxyalkanoates (PHAs) have become an attractive biomaterial in research in the past few years due to their extensive potential industrial applications. Being long chain hydroxyl fatty acid molecules, the PHAs are hydrophobic in nature, and have less functional groups. These features limit their applications in various areas. To enhance their usage, these polymers may need to be modified including surface and chemical modifications. Such modifications may alter their mechanical properties, surface structure, amphiphilic character and rate of degradation to fulfil the requirements for their future applications. Chemical modifications allow incorporation of functional groups to PHAs that could not be introduced through biotechnological methods. These chemically reformed PHAs, with enhanced properties, could be used for broad range of applications. This review aims to introduce different chemical modification approaches including some recent methods that had not been explored or discussed so far for PHAs as possible technologies for widening the range of product and application potentials. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:29-41, 2018.
在过去几年中，聚羟基脂肪酸酯（PHA）因其广泛的潜在工业应用，已成为研究中一种具有吸引力的生物材料。作为长链羟基脂肪酸分子，PHA本质上是疏水的，且官能团较少。这些特性限制了它们在各个领域的应用。为了增加其用途，可能需要对这些聚合物进行改性，包括表面改性和化学改性。此类改性可能会改变它们的机械性能、表面结构、两亲性特征和降解速率，以满足其未来应用的要求。化学改性能够将通过生物技术方法无法引入的官能团引入到PHA中。这些经过化学改造、性能增强的PHA可用于广泛的应用。本综述旨在介绍不同的化学改性方法，包括一些迄今为止尚未探索或讨论过的用于PHA的最新方法，这些方法有可能成为拓宽产品范围和应用潜力的技术。© 2017美国化学工程师学会 生物技术进展，34:29 - 41，2018。
