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提高聚羟基脂肪酸酯在组织工程应用中的潜力：化学改性方法综述

Enhancing the Potential of PHAs in Tissue Engineering Applications: A Review of Chemical Modification Methods.

作者信息

Chaber Paweł, Andrä-Żmuda Silke, Śmigiel-Gac Natalia, Zięba Magdalena, Dawid Kamil, Martinka Maksymiak Magdalena, Adamus Grażyna

机构信息

Centre of Polymer and Carbon Materials, Polish Academy of Sciences, ul. M. Curie-Skłodowska 34, 41-819 Zabrze, Poland.

Department of Optoelectronics, Silesian University of Technology, ul. B. Krzywoustego 2, 44-100 Gliwice, Poland.

出版信息

Materials (Basel). 2024 Nov 27;17(23):5829. doi: 10.3390/ma17235829.

DOI:10.3390/ma17235829
PMID:39685265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11642177/
Abstract

Polyhydroxyalkanoates (PHAs) are a family of polyesters produced by many microbial species. These naturally occurring polymers are widely used in tissue engineering because of their in vivo degradability and excellent biocompatibility. The best studied among them is poly(3-hydroxybutyrate) (PHB) and its copolymer with 3-hydroxyvaleric acid (PHBV). Despite their superior properties, PHB and PHBV suffer from high crystallinity, poor mechanical properties, a slow resorption rate, and inherent hydrophobicity. Not only are PHB and PHBV hydrophobic, but almost all members of the PHA family struggle because of this characteristic. One can overcome the limitations of microbial polyesters by modifying their bulk or surface chemical composition. Therefore, researchers have put much effort into developing methods for the chemical modification of PHAs. This paper explores a rarely addressed topic in review articles-chemical methods for modifying the structure of PHB and PHBV to enhance their suitability as biomaterials for tissue engineering applications. Different chemical strategies for improving the wettability and mechanical properties of PHA scaffolds are discussed in this review. The properties of PHAs that are important for their applications in tissue engineering are also discussed.

摘要

聚羟基脂肪酸酯（PHA）是一类由多种微生物产生的聚酯。这些天然存在的聚合物因其在体内的可降解性和优异的生物相容性而被广泛应用于组织工程。其中研究最多的是聚（3-羟基丁酸酯）（PHB）及其与3-羟基戊酸的共聚物（PHBV）。尽管PHB和PHBV具有优异的性能，但它们存在结晶度高、机械性能差、吸收速率慢以及固有的疏水性等问题。不仅PHB和PHBV具有疏水性，而且PHA家族的几乎所有成员都受此特性困扰。通过改变其本体或表面化学成分，可以克服微生物聚酯的局限性。因此，研究人员在开发PHA化学改性方法方面付出了很多努力。本文探讨了综述文章中很少涉及的一个话题——化学方法修饰PHB和PHBV的结构，以提高它们作为组织工程应用生物材料的适用性。本综述讨论了改善PHA支架润湿性和机械性能的不同化学策略。还讨论了PHA在组织工程应用中重要的性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4524/11642177/9c70207f754b/materials-17-05829-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4524/11642177/85879b228a41/materials-17-05829-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4524/11642177/01acf96b0b3f/materials-17-05829-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4524/11642177/7c60abd34466/materials-17-05829-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4524/11642177/3adc8ebbb418/materials-17-05829-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4524/11642177/f04f383c18f8/materials-17-05829-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4524/11642177/485240590011/materials-17-05829-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4524/11642177/9c70207f754b/materials-17-05829-g012.jpg

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本文引用的文献

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Synthesis and characterization of self-healing bio-based polyurethane from microbial poly(3-hydroxybutyrate) produced in methanotrophs.由甲烷营养菌产生的微生物聚 3-羟基丁酸酯合成并表征自修复生物基聚氨酯。
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Natural Polyhydroxyalkanoates-An Overview of Bacterial Production Methods.
天然聚羟基烷酸酯——细菌生产方法概述。
Molecules. 2024 May 13;29(10):2293. doi: 10.3390/molecules29102293.
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Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review.揭示压电聚合物在神经组织再生中的重要作用：综述。
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PHA is not just a bioplastic!PHA 不仅仅是一种生物塑料！
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Current advances and emerging trends in sustainable polyhydroxyalkanoate modification from organic waste streams for material applications.有机废物流中可持续性聚羟基烷酸酯改性用于材料应用的最新进展和新兴趋势。
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