Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM).
Department of Experimental and Health Sciences (DCEXS), Universitat Pompeu Fabra (UPF).
Bioinformatics. 2017 Dec 15;33(24):4004-4006. doi: 10.1093/bioinformatics/btx506.
Psychiatric disorders have a great impact on morbidity and mortality. Genotype-phenotype resources for psychiatric diseases are key to enable the translation of research findings to a better care of patients. PsyGeNET is a knowledge resource on psychiatric diseases and their genes, developed by text mining and curated by domain experts.
We present psygenet2r, an R package that contains a variety of functions for leveraging PsyGeNET database and facilitating its analysis and interpretation. The package offers different types of queries to the database along with variety of analysis and visualization tools, including the study of the anatomical structures in which the genes are expressed and gaining insight of gene's molecular function. Psygenet2r is especially suited for network medicine analysis of psychiatric disorders.
The package is implemented in R and is available under MIT license from Bioconductor (http://bioconductor.org/packages/release/bioc/html/psygenet2r.html).
juanr.gonzalez@isglobal.org or laura.furlong@upf.edu.
Supplementary data are available at Bioinformatics online.
精神疾病对发病率和死亡率有很大影响。精神疾病的基因型-表型资源是将研究结果转化为更好的患者护理的关键。PsyGeNET 是一个关于精神疾病及其基因的知识资源，由文本挖掘开发，并由领域专家进行整理。
我们介绍了 psygenet2r，这是一个 R 包，包含了各种功能，可以利用 PsyGeNET 数据库，并促进其分析和解释。该软件包提供了不同类型的数据库查询，以及各种分析和可视化工具，包括研究基因表达的解剖结构，并深入了解基因的分子功能。psygenet2r 特别适合于精神障碍的网络医学分析。
该软件包是用 R 编写的，并根据麻省理工学院的许可证在 Bioconductor （http://bioconductor.org/packages/release/bioc/html/psygenet2r.html）上提供。
juanr.gonzalez@isglobal.org 或 laura.furlong@upf.edu。
补充数据可在 Bioinformatics 在线获得。
