Amornsiripanitch S, Barnes L M, Nordlund J J, Trinkle L S, Rheins L A
Department of Dermatology, University of Cincinnati College of Medicine, OH 45267.
J Immunol. 1988 May 15;140(10):3438-45.
Vitiligo is a human disorder which destroys pigment cells in the skin, ears, eyes, and meningeal tissues and has often been associated with a variety of autoimmune disorders. The C57BL/Ler-vit/vit mouse is a mutant strain that exhibits a loss of epidermal pigment cells and a selective cell-mediated immune deficiency to epicutaneous-administered allergens. This observation is consistent with that observed in humans with vitiligo, who also exhibit loss of contact hypersensitivity (CHS), that appears to be associated with loss of pigment cells from the epidermis. Other cellular immune parameters such as delayed type hypersensitivity and antibody generation to both particulate and soluble Ag are normal or even hyperimmune in the vit/vit mice compared with congenic C57BL/6 controls. Cyclophosphamide treatment could reconstitute CHS responsiveness of the vit/vit mice to the allergen dinitrofluorobenzene. Further, this loss of CHS responsiveness to dinitrofluorobenzene could be restored with skin transplants from normal pigmented C57BL/6 mice to vit/vit mice. Normal C57BL/6 mice bearing white skin grafts from vit/vit mice did not contact sensitize. We suggest that this vit/vit mouse strain may serve as an excellent system to investigate various aspects of other contact hypersensitivity reactions as well as vitiligo.
白癜风是一种人类疾病，它会破坏皮肤、耳朵、眼睛和脑膜组织中的色素细胞，并且常常与多种自身免疫性疾病相关。C57BL/Ler-vit/vit小鼠是一种突变品系，表现出表皮色素细胞缺失以及对经皮给予的过敏原的选择性细胞介导免疫缺陷。这一观察结果与白癜风患者中观察到的情况一致，白癜风患者也表现出接触性超敏反应（CHS）丧失，这似乎与表皮色素细胞丧失有关。与同基因C57BL/6对照相比，vit/vit小鼠的其他细胞免疫参数，如迟发型超敏反应以及对颗粒性和可溶性抗原的抗体产生，均正常甚至超免疫。环磷酰胺治疗可恢复vit/vit小鼠对过敏原二硝基氟苯的CHS反应性。此外，将正常色素沉着的C57BL/6小鼠的皮肤移植到vit/vit小鼠可恢复其对二硝基氟苯的CHS反应性丧失。接受来自vit/vit小鼠白色皮肤移植的正常C57BL/6小鼠不会产生接触致敏。我们认为，这种vit/vit小鼠品系可能是研究其他接触性超敏反应以及白癜风各个方面的优秀模型。
