[受照射机体组织中环状核苷酸系统的变化]
[Changes in the system of cyclic nucleotides in irradiated body tissues].
作者信息
Vladimirov V G, Antushevich A E
出版信息
Radiobiologiia. 1988 Mar-Apr;28(2):201-4.
It has been shown that the content of cAMP in the rat thymus, spleen, and liver 1 and 3 days after gamma-radiation with 7.5 Gy decreases, and that of cGMP increases. Analogous dynamics has been revealed when studying adenylate cyclase and guanylate cyclase activities. The activity of cAMP and cGMP phosphodiesterases increased during the first period of study but subsequently it showed no distinction from the initial data level. The revealed postradiation changes in the content of cyclic nucleotides seem to be basically caused by the cyclases activity alterations.
结果显示，大鼠经7.5 Gy γ射线照射后1天和3天，其胸腺、脾脏和肝脏中的环磷酸腺苷（cAMP）含量降低，而环磷酸鸟苷（cGMP）含量升高。在研究腺苷酸环化酶和鸟苷酸环化酶活性时也发现了类似的动态变化。在研究的第一阶段，cAMP和cGMP磷酸二酯酶的活性增加，但随后与初始数据水平无差异。所揭示的辐射后环核苷酸含量的变化似乎主要是由环化酶活性改变引起的。
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