Dittrich A-M
Klinik für pädiatrische Pneumologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
Internist (Berl). 2017 Nov;58(11):1133-1141. doi: 10.1007/s00108-017-0327-8.
Pseudomonas aeruginosa (PsA) is a hallmark pathogen of the lung disease in cystic fibrosis (CF) patients. Chronic PsA colonization is a central factor in the course of CF lung disease. PsA contributes considerably to morbidity and mortality, and also has a significant impact on quality of life and the costs of CF treatment. Prevention of chronic colonization has therefore been a major goal in the treatment of CF patients for many years now. In the present article, studies are presented which suggest that prevention of chronic colonization can be achieved. Approaches to prevent chronic PsA colonization are critically evaluated and recommendations for preventative approaches are generated from this discussion.
铜绿假单胞菌（PsA）是囊性纤维化（CF）患者肺部疾病的标志性病原体。PsA的慢性定植是CF肺部疾病病程中的一个核心因素。PsA对发病率和死亡率有很大影响，也对生活质量和CF治疗成本有重大影响。因此，多年来预防慢性定植一直是CF患者治疗的主要目标。在本文中，介绍了一些研究，这些研究表明可以实现预防慢性定植。对预防PsA慢性定植的方法进行了批判性评估，并从该讨论中得出了预防方法的建议。
