Petkov V D, Getova D, Mosharrof A H
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Acta Physiol Pharmacol Bulg. 1987;13(4):25-30.
The effects of adafenoxate (100 mg/kg), aniracetam (50 mg/kg), meclofenoxate (100 mg/kg), piracetam (250 mg/kg), and standardized ginseng extract-G115 (100 mg/kg) applied for five days were studied with Vogel's conflict procedure in which thirsty naive rats were periodically administered shocks for licking water. The results showed a significant anti-anxiety effect (increases in licking) with adafenoxate and meclofenoxate. Piracetam significantly suppressed licking behaviour and this effect was evaluated as anxiogenic (resulting from the non-specific stimulant action of the drug). Adafenoxate was found to increase also the number of entries into and escapes from the dark compartment without punishment responding. This effect of adafenoxate was considered to be an expression of facilitated conditioned-reflex activity. A beneficial role for the observed anti-anxiety effects of adafenoxate and meclofenoxate in the nootropic action of these drugs is suggested.
采用Vogel冲突程序研究了连续五天给予阿屈非奈（100毫克/千克）、茴拉西坦（50毫克/千克）、甲氯芬酯（100毫克/千克）、吡拉西坦（250毫克/千克）和标准化人参提取物-G115（100毫克/千克）的效果，在该程序中，口渴的未经验大鼠因舔水而定期受到电击。结果显示，阿屈非奈和甲氯芬酯具有显著的抗焦虑作用（舔舐增加）。吡拉西坦显著抑制舔舐行为，这种作用被评估为致焦虑作用（由药物的非特异性兴奋作用引起）。还发现阿屈非奈增加了进入和逃离暗室的次数，且无惩罚反应。阿屈非奈的这种作用被认为是条件反射活动增强的表现。提示阿屈非奈和甲氯芬酯观察到的抗焦虑作用在这些药物的促智作用中具有有益作用。
