Ngo Carine, Albert Sébastien, Barry Beatrix, Copie-Bergman Christiane, Couvelard Anne, Hourseau Muriel
Service d'anatomie et de cytologie pathologiques, hôpital Bichat, 46, rue Henri-Huchard, 75018 Paris, France.
Service de chirurgie ORL, 46, rue Henri-Huchard, 75018 Paris, France.
Ann Pathol. 2017 Oct;37(5):420-424. doi: 10.1016/j.annpat.2017.06.025. Epub 2017 Sep 28.
We report the case of a 65-year-old woman who presented with a dysphonia. ENT tomography and laryngoscopy showed an endolaryngeal tumoral lesion extended to the right supraglottis. Biopsy of the lesion revealed dense lymphoid infiltrate in the lamina propria, without necrosis or ulceration of the mucosa. The infiltrate showed many CD3+, CD5+, CD4+, CD8+ lymphocytes and plasmocytes. Larger lymphoid cells with cytologic atypia expressed CD56 and cytotoxicity markers such as TIA1 and granzyme B. In situ hybridization for EBV revealed numerous positive cells. The diagnosis of extranodal NK/T cell lymphoma was proposed. The primary laryngeal localization of this disease is exceptionally rare. Heavy admixture of inflammatory cells may mimic inflammatory process and delay the diagnosis.