Patel D, Patel N, Brennan P A, Kwok J
Department of Oral Surgery, Guy's Hospital, Great Maze Pond, London, SE1 9RT.
Department of Oral Surgery, Guy's Hospital, Great Maze Pond, London, SE1 9RT.
Br J Oral Maxillofac Surg. 2017 Nov;55(9):932-936. doi: 10.1016/j.bjoms.2017.08.370. Epub 2017 Sep 28.
Cleidocranial dysplasia is a hereditary congenital disorder that results in delayed ossification of midline structures, and is caused by mutations in the RunX2 (runt-related transcription factor 2) gene located on the short arm of chromosome 6. Successful treatment depends on multidisciplinary assessment and a comprehensive staged treatment plan. We present a case series of 12 patients who were managed with a specifically tailored combination of surgery, orthodontics, and prosthodontics to provide a functional dentition and restore their smile and facial contour. Successful dental rehabilitation can be challenging in this group because patients often have multiple dental anomalies and a reduced quantity and density of alveolar bone. Rehabilitation with early intervention and a carefully planned multidisciplinary approach has been successful in the long term.
锁骨颅骨发育不全是一种遗传性先天性疾病，可导致中线结构骨化延迟，由位于6号染色体短臂上的RunX2（ runt相关转录因子2）基因突变引起。成功的治疗取决于多学科评估和全面的分期治疗计划。我们报告了一个包含12例患者的病例系列，这些患者接受了专门定制的手术、正畸和修复治疗组合，以提供功能性牙列并恢复他们的笑容和面部轮廓。在这组患者中，成功的牙齿修复可能具有挑战性，因为患者通常存在多种牙齿异常，并且牙槽骨的数量和密度降低。通过早期干预和精心规划的多学科方法进行修复在长期来看是成功的。
