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子宫内膜癌的差异:对文献的种族意识批判。

Endometrial cancer disparities: a race-conscious critique of the literature.

机构信息

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA; Seattle Cancer Care Alliance, Seattle, WA.

Department of Family Medicine, School of Medicine, University of Washington, Seattle, WA.

出版信息

Am J Obstet Gynecol. 2018 May;218(5):474-482.e2. doi: 10.1016/j.ajog.2017.09.016. Epub 2017 Sep 28.

Abstract

Racial disparities in endometrial cancer are stark and have increased over the past decade. While the disparities are well documented, intervention work to address the mortality gap is nonexistent. This review critiques how race has been conceptualized to explain the causes of endometrial cancer disparities, assesses gaps in knowledge production, and proposes new research priorities. Using public health critical race praxis, a research approach for examining racial disparities and knowledge production processes, we reviewed the endometrial cancer disparities literature from 1995 through 2016. Using systematic search methods, 133 unique records were identified and 48 studies critiqued. We found that a narrow definition of race as a purely biological construct is common throughout the literature. This appears to result in an underemphasis on the role of modifiable, nonbiological contributors to racial disparities and a lack of follow-up work to address these contributors. Key knowledge gaps identified were the role of health care systems in early diagnosis, a lack of intervention studies to address persistent treatment inequity by race, and the near absence of qualitative work to understand the perspectives of Black women diagnosed with endometrial cancer. We conclude with an iterative demonstration of the public health critical race praxis and suggest new routes of inquiry to broaden the scope of research priorities to understand and improve the outcomes of Black women with endometrial cancer.

摘要

子宫内膜癌的种族差异明显,并在过去十年中有所增加。尽管这些差异得到了充分的记录,但针对死亡率差距的干预工作却不存在。本综述批评了种族概念化如何解释子宫内膜癌差异的原因,评估了知识生产的差距,并提出了新的研究重点。我们使用公共卫生关键种族实践,这是一种用于检查种族差异和知识生产过程的研究方法,回顾了 1995 年至 2016 年的子宫内膜癌差异文献。使用系统搜索方法,确定了 133 个独特的记录,并对 48 项研究进行了评论。我们发现,文献中普遍存在将种族狭隘地定义为纯粹的生物结构的现象。这似乎导致对可改变的、非生物因素对种族差异的作用重视不够,也缺乏后续工作来解决这些因素。确定的主要知识差距包括医疗保健系统在早期诊断中的作用、缺乏针对种族间持续治疗不平等的干预研究,以及几乎没有定性工作来了解被诊断患有子宫内膜癌的黑人女性的观点。最后,我们以迭代的方式展示了公共卫生关键种族实践,并提出了新的研究途径,以扩大研究重点的范围,以了解和改善黑人女性的子宫内膜癌结局。

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