Nakane T, Chiba S
Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Arch Int Pharmacodyn Ther. 1988 Jan-Feb;291:153-62.
The cannula-inserting method was used to examine the vascular responses of the isolated, perfused dog and monkey coronary arteries to a calcium antagonist (diltiazem), adrenergic beta-blockers (propranolol and pindolol), an antianginal drug (nicorandil) and vasodilators (hydralazine and papaverine). Propranolol and pindolol constricted the dog and monkey coronary arteries dose-dependently. Without any precontraction, hydralazine produced a biphasic response--a vasodilatation followed by a vasoconstriction--in the dog coronary artery, although it produced only a vasodilatation in the monkey coronary artery. Nicorandil and diltiazem dilated the uncontracted dog and monkey coronary arteries dose-dependently. The rank order of drug potency for inducing vasodilatation was diltiazem greater than nicorandil greater than hydralazine in both coronary arteries. These results indicate that the cannula-inserting method is useful to investigate the responses of the large epicardial dog and monkey coronary arteries to vasodilating drugs.
采用插管法检测了离体灌注的犬和猴冠状动脉对钙拮抗剂（地尔硫䓬）、肾上腺素能β受体阻滞剂（普萘洛尔和吲哚洛尔）、抗心绞痛药物（尼可地尔）和血管扩张剂（肼屈嗪和罂粟碱）的血管反应。普萘洛尔和吲哚洛尔使犬和猴冠状动脉呈剂量依赖性收缩。在无任何预收缩的情况下，肼屈嗪在犬冠状动脉中产生双相反应——先血管扩张后血管收缩——尽管它在猴冠状动脉中仅产生血管扩张作用。尼可地尔和地尔硫䓬使未收缩的犬和猴冠状动脉呈剂量依赖性扩张。在两条冠状动脉中，诱导血管扩张的药物效力顺序为地尔硫䓬＞尼可地尔＞肼屈嗪。这些结果表明，插管法有助于研究犬和猴心外膜大冠状动脉对血管扩张药物的反应。
