慢性反复性腿部缺血对急性冠脉综合征患者左心室功能和冠状动脉粥样硬化严重程度的影响。

The Impact of Chronic Repetitive Leg Ischemia on Left Ventricular Function and Severity of Coronary Atherosclerosis in Patients with Acute Coronary Syndrome.

机构信息

Department of Cardiology, Memorial Sisli Hospital, Istanbul, Turkey.

出版信息

Med Princ Pract. 2017;26(5):447-450. doi: 10.1159/000481866. Epub 2017 Oct 1.

DOI:10.1159/000481866

PMID:28965111

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5757566/

Abstract

OBJECTIVE

The purpose of this study was to assess the impact of the presence of peripheral arterial disease (PAD) on left ventricular (LV) function in patients with coronary artery disease (CAD) presenting with acute coronary syndrome (ACS).

SUBJECTS AND METHODS

The medical records of the patients who were referred to Ankara Bayindir Hospital, Ankara, Turkey, due to a first episode of ACS were reviewed. Patients with concomitant PAD and CAD (group 1) were compared with those who had CAD only (group 2). The Mann-Whitney U and χ2 tests were used to compare continuous and categorical variables, respectively.

RESULTS

Baseline demographic data of 53 patients with PAD + CAD (42 men and 11 women; mean age 62.5 ± 9.5 years) and a group of 60 patients with CAD only (41 men and 19 women; mean age 59.9 ± 9.8 years) were similar, except for the serum creatinine level which was higher in group 1 than in group 2 (1.32 ± 0.34 vs. 1.03 ± 0.22 mg/dL, p < 0.001). Patients with CAD + PAD had significantly higher Gensini scores (62.6 ± 19.7 vs. 41.4 ± 26.8, p = 0.004) and more 3-vessel disease than patients with CAD alone (62.2 vs. 31.6%, p < 0.045). There was a significant difference between the 2 groups regarding the LV ejection fraction at the time of the diagnosis (52.0 ± 8.2% in the CAD + PAD group and 43.7 ± 13.3% in the CAD-alone group; p = 0.017).

CONCLUSION

CAD concomitant with PAD was associated with preserved LV function at early stages of diagnosis in patients with ACS.

摘要

目的

本研究旨在评估伴有外周动脉疾病（PAD）的冠心病（CAD）合并急性冠状动脉综合征（ACS）患者左心室（LV）功能的变化。

方法

回顾性分析土耳其安卡拉 Bayindir 医院因首次 ACS 就诊的患者的病历。将同时患有 CAD 和 PAD 的患者（组 1）与仅患有 CAD 的患者（组 2）进行比较。采用 Mann-Whitney U 检验和 χ2 检验分别比较连续变量和分类变量。

结果

53 例 PAD+CAD 患者（42 例男性，11 例女性；平均年龄 62.5±9.5 岁）和 60 例仅 CAD 患者（41 例男性，19 例女性；平均年龄 59.9±9.8 岁）的基线人口统计学数据相似，但组 1 的血清肌酐水平高于组 2（1.32±0.34 对 1.03±0.22mg/dL，p＜0.001）。与仅 CAD 患者相比，CAD+PAD 患者的 Gensini 评分（62.6±19.7 对 41.4±26.8，p=0.004）更高，3 支血管病变的比例也更高（62.2%对 31.6%，p＜0.045）。在诊断时，2 组间的 LV 射血分数有显著差异（CAD+PAD 组为 52.0±8.2%，CAD 组为 43.7±13.3%；p=0.017）。