Castiglione Fabio, Ralph David J, Muneer Asif
Department of Andrology, University College London Hospital, 250 Euston Road, London, NW1 2PG, UK.
NIHR Biomedical Research Centre, University College London Hospital, London, UK.
Curr Urol Rep. 2017 Sep 30;18(11):90. doi: 10.1007/s11934-017-0735-2.
Due to the increasing numbers of radical prostatectomies (RP) performed for prostate cancer, a substantial number of patients are now suffering from post-operative erectile dysfunction (ED). The aim of this study is to summarize the current literature on surgical techniques for managing post-prostatectomy erectile dysfunction.
The PubMed database was searched for English-language articles published up to Jan 2017 using the following search terms: "prostatectomy AND erectile dysfunction", "prostatectomy AND penile prostheses", and "prostatectomy AND penile implants". All of the studies that evaluated medical treatment were excluded. In the last few decades, the understanding of the anatomy of the male pelvis and prostate has improved. This has led to significant changes in the nerve-sparing radical prostatectomy techniques, with the aim of preserving post-surgical erectile function (EF). In this scenario, the prostate vascular supply and the anatomy of the neurovascular bundles have a central role. Penile prosthesis implantation is considered the third-line treatment option for RP ED patients, and they have been reported to be a very successful treatment with the highest patient satisfaction rate. Considering the failure of penile rehabilitation, and the lack of evidence for accessory pudendal artery (APA) preservation and nerve graft, nerve-sparing surgery and penile prostheses represent, today, the only methods to permanently and definitively preserve or erectile function after RP.
由于因前列腺癌而进行的根治性前列腺切除术(RP)数量不断增加,现在有相当数量的患者术后患有勃起功能障碍(ED)。本研究的目的是总结目前关于治疗前列腺切除术后勃起功能障碍的手术技术的文献。
使用以下搜索词在PubMed数据库中检索截至2017年1月发表的英文文章:“前列腺切除术与勃起功能障碍”、“前列腺切除术与阴茎假体”以及“前列腺切除术与阴茎植入物”。所有评估药物治疗的研究均被排除。在过去几十年中,对男性骨盆和前列腺解剖结构的认识有所提高。这导致了保留神经的根治性前列腺切除术技术发生了重大变化,目的是保留术后勃起功能(EF)。在这种情况下,前列腺血管供应和神经血管束的解剖结构起着核心作用。阴茎假体植入被认为是RP ED患者的三线治疗选择,据报道这是一种非常成功的治疗方法,患者满意度最高。考虑到阴茎康复失败,以及缺乏保留阴部副动脉(APA)和神经移植的证据,保留神经手术和阴茎假体目前是RP后永久且明确保留勃起功能的唯一方法。