Wang Lei, Liu Zhi-Yong, Piao Shu-Guang, Xu Chuan-Liang, Hou Jian-Guo, Gao Xu, Sun Ying-Hao
Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
Zhonghua Nan Ke Xue. 2016 Jul;22(7):626-629.
To investigate the treatment of azoospermia induced by iatrogenic injury to the bilateral vas deferens.
We retrospectively analyzed 11 cases of azoospermia caused by iatrogenic injury to bilateral vas deferens. The patients were aged 20-33 years, all diagnosed with azoospermia preoperatively and none with a history of pelvic operation. Seven of them had received bilateral inguinal hernia repair and the other 4 undergone bilateral orchidopexy in the childhood.
Intraoperative exploration of the bilateral inguinal region was performed in all the patients. Bilateral vas deference atresia was found in the inguinal canal in 6 cases, which was treated by microscopic vasovasostomy following removal of the atresic segment. Vas deferens residual was observed in or near the deep inguinal ring in the other 5 cases, with the distal vas deferens inaccessible, which was treated by bilateral vasovasostomy in 3 cases and unilateral vasovasostomy in 2 (for longer defect segment than could be anastomosed) following combined laparoscopic exploration of the abdominal cavity. The patients were followed up for 3-12 months postoperatively, during which sperm were detected in 7 cases, with sperm concentration ranging from 0.4×10⁶/ml to 35×10⁶/ml and grade a+b sperm from 15% to 46%.
For the diagnosis of azoospermia, especially in patients with no history of pelvic operation, special attention should be paid to iatrogenic injury to the vas deferens. For the treatment of the disease, non-tension vasovasostomy is essential and, when necessary, the vas deferens can be reconstructed by changing its anatomical path and shortening its length.
探讨医源性双侧输精管损伤所致无精子症的治疗方法。
回顾性分析11例医源性双侧输精管损伤所致无精子症患者。患者年龄20 - 33岁,术前均诊断为无精子症,均无盆腔手术史。其中7例曾行双侧腹股沟疝修补术,另外4例在儿童期行双侧睾丸固定术。
所有患者均行双侧腹股沟区术中探查。6例在腹股沟管发现双侧输精管闭锁,切除闭锁段后行显微输精管吻合术。另外5例在腹股沟深环处或其附近观察到输精管残留,远端输精管无法触及,其中3例行双侧输精管吻合术,2例(因缺损段过长无法吻合)在联合腹腔镜探查腹腔后行单侧输精管吻合术。术后对患者随访3 - 12个月,期间7例检测到精子,精子浓度为0.4×10⁶/ml至35×10⁶/ml,a + b级精子为15%至46%。
对于无精子症的诊断,尤其是无盆腔手术史的患者,应特别注意医源性输精管损伤。对于该病的治疗,无张力输精管吻合术至关重要,必要时可通过改变输精管解剖路径和缩短其长度来进行输精管重建。