Koepfli Cristian, Mueller Ivo
University of California Irvine, Irvine, CA, USA; Walter and Eliza Hall Institute for Medical Research, Parkville, Australia; Department of Medical Biology, University of Melbourne, Parkville, Australia.
Walter and Eliza Hall Institute for Medical Research, Parkville, Australia; Department of Medical Biology, University of Melbourne, Parkville, Australia; Malaria: Parasites & Hosts Unit, Department of Parasites & Insect Vectors, Institut Pasteur, Paris, France.
Trends Parasitol. 2017 Dec;33(12):974-985. doi: 10.1016/j.pt.2017.08.013. Epub 2017 Sep 28.
Genotyping to distinguish between parasite clones is nowadays a standard in many molecular epidemiological studies of malaria. It has become crucial in drug trials and to follow individual clones in epidemiological studies, and to understand how drug resistance emerges and spreads. Here, we review the applications of the increasingly available genotyping tools and whole-genome sequencing data, and argue for a better integration of population genetics findings into malaria-control strategies.
如今,在许多疟疾分子流行病学研究中,区分寄生虫克隆的基因分型已成为标准做法。在药物试验中,以及在流行病学研究中追踪单个克隆,并了解耐药性如何出现和传播,基因分型都变得至关重要。在此,我们回顾了日益可用的基因分型工具和全基因组测序数据的应用,并主张将群体遗传学研究结果更好地整合到疟疾控制策略中。