Tiewsoh Jutang Babat Ain, Dias Meena
Department of Microbiology, Fr. Muller Medical College, Mangalore, Karnataka, India.
J Lab Physicians. 2017 Oct-Dec;9(4):239-242. doi: 10.4103/0974-2727.214262.
is the most common pathogen causing infection in hospitals. They also colonize the healthcare workers who serve as reservoir of infection. Emergence of methicillin-resistant (MRSA) is a burning issue throughout the world contributing to significant morbidity and mortality. Use of mupirocin to eradicate the carrier state is the need of the hour.
To screen healthcare workers (HCWs) and medical students for MRSA and to know the susceptibility of mupirocin in this group.
A total of 432 students, nursing staff, doctors and house-keeping staff were screened for MRSA for 4 months. The MRSA and methicillin-resistant coagulase-negative (MRCoNS) isolates were then tested for mupirocin resistance.
Out of 432 samples, 24 (5.55%) were MRSA and 104 (24.07%) were MRCoNS. Only 4.16% ( = 1) showed high-level resistance to mupirocin among the MRSA isolates, while resistance among MRCoNS was higher at 6.7% ( = 7) for low-level resistance and 17.30% ( = 18) for high-level resistance.
MRSA colonization of HCWs may serve as a source of infection and mupirocin resistance should be screened for all whether working in Intensive Care Units or not and if detected, alternative treatment should be used which will result in appropriate use of this antibiotic for decolonization.
是医院感染最常见的病原体。它们还定植于医护人员，而医护人员是感染的储存宿主。耐甲氧西林（MRSA）的出现是一个全球性的紧迫问题，会导致显著的发病率和死亡率。使用莫匹罗星消除携带状态是当务之急。
筛查医护人员（HCWs）和医学生中的MRSA，并了解该群体对莫匹罗星的敏感性。
在4个月内对总共432名学生、护理人员、医生和保洁人员进行了MRSA筛查。然后对MRSA和耐甲氧西林凝固酶阴性（MRCoNS）分离株进行莫匹罗星耐药性检测。
在432份样本中，24份（5.55%）为MRSA，104份（24.07%）为MRCoNS。在MRSA分离株中，只有4.16%（=1）对莫匹罗星表现出高水平耐药，而MRCoNS中的耐药率较高，低水平耐药为6.7%（=7），高水平耐药为17.30%（=18）。
医护人员的MRSA定植可能是感染源，无论是否在重症监护病房工作，都应对所有人进行莫匹罗星耐药性筛查，如果检测到耐药，应使用替代治疗，这将导致该抗生素在去定植方面的合理使用。
