Dietch J T, Jennings R K
Department of Psychiatry, University of California Irvine Medical Center, Orange 92668.
J Clin Psychiatry. 1988 May;49(5):184-8.
Periodic reports have suggested that benzodiazepines may be associated with a loss of control over aggressive impulses. Manifestations range from irritability to increased verbal hostility to frank assault. After reviewing data from case reports, experimental studies, and incidence reports, the authors attempt to characterize the phenomenon, estimate the incidence of clinically adverse sequelae to be less than 1%, and find consistent predictive indicators lacking.
定期报告表明，苯二氮䓬类药物可能与攻击冲动失控有关。表现形式从易怒到言语攻击性增强，直至公然攻击。在回顾了病例报告、实验研究和发病率报告的数据后，作者试图描述这一现象，估计临床不良后果的发生率低于1%，并发现缺乏一致的预测指标。
