使用定制光学相干断层扫描潜望镜对人类尸检眼进行视网膜成像。
Retinal imaging in human autopsy eyes using a custom optical coherence tomography periscope.
作者信息
McNabb Ryan P, Tian James, Farsiu Sina, Izatt Joseph A, Lad Eleonora M, Kuo Anthony N
机构信息
Department of Ophthalmology, Duke University Medical Center, 2351 Erwin Rd, Durham, NC 27705, USA.
Department of Biomedical Engineering, Duke University, 101 Science Drive, Durham, NC 27708, USA.
出版信息
Biomed Opt Express. 2017 Aug 21;8(9):4152-4159. doi: 10.1364/BOE.8.004152. eCollection 2017 Sep 1.
Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly. To better study the pathobiology of AMD, postmortem eyes offer an excellent opportunity to correlate optical coherence tomography (OCT) imaging characteristics with histopathology. However, postmortem eyes from autopsy present challenges to standard OCT imaging including opaque anterior segment structures and standard of care autopsy processing resulting in oblique views to the macula. To overcome these challenges, we report a custom periscope attached by a standard mount to an OCT sample arm and demonstrate high quality macular OCT acquisitions in autopsy-processed eyes.
年龄相关性黄斑变性（AMD）是老年人视力丧失的主要原因。为了更好地研究AMD的病理生物学，死后眼球为将光学相干断层扫描（OCT）成像特征与组织病理学相关联提供了绝佳机会。然而，尸检获得的死后眼球给标准OCT成像带来了挑战，包括眼前节结构不透明以及尸检处理的护理标准导致黄斑的倾斜视图。为了克服这些挑战，我们报告了一种通过标准支架连接到OCT样本臂的定制潜望镜，并展示了在经尸检处理的眼球中高质量的黄斑OCT采集。
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