Sacks T
Department of Clinical Microbiology, Hadassah University Hospital, Jerusalem, Israel.
J Hosp Infect. 1988 Feb;11 Suppl A:251-8. doi: 10.1016/0195-6701(88)90195-8.
There is well-documented evidence justifying, perhaps demanding, the obligatory use of early, anticipatory treatment in open fractures and in penetrating abdominal wounds, and equally convincing evidence that they are not indicated in fractures of the base of the skull with CSF leaks, in thermal injuries, or in simple lacerations. As far as penetrating chest wounds, and bites are concerned, the evidence is perhaps as yet inconclusive, but antibiotics are probably not indicated in these situations.
有充分记录的证据表明，在开放性骨折和腹部穿透伤中进行早期、预防性治疗是合理的，甚至可能是必要的；同样有令人信服的证据表明，在伴有脑脊液漏的颅底骨折、热损伤或单纯裂伤中，不适用这种治疗。至于穿透性胸部伤口和咬伤，目前证据可能尚不确凿，但在这些情况下可能无需使用抗生素。
