Miller Rachel E, Malfait Anne-Marie, Block Joel A
Department of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago IL, USA.
Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):85-87. Epub 2017 Sep 28.
Blockade of nerve growth factor (NGF) with antibodies is a promising strategy for treatment of chronic pain associated with osteoarthritis (OA). This narrative review describes the current status of NGF-blockade for the treatment of OA pain. We summarise briefly current evidence for the efficacy and risks of anti-NGF blockade. Two anti-NGF antibodies, tanuzemab and fasinumab, are in active development, with tanuzemabclose to completing Phase 3 trials in preparation for an application for approval for clinical use.
用抗体阻断神经生长因子(NGF)是治疗与骨关节炎(OA)相关慢性疼痛的一种有前景的策略。本叙述性综述描述了NGF阻断治疗OA疼痛的现状。我们简要总结了抗NGF阻断疗效和风险的当前证据。两种抗NGF抗体,即他努泽单抗和法西努单抗,正处于积极研发中,其中他努泽单抗已接近完成3期试验,为申请临床使用批准做准备。