Volosin M, Cancela L, Molina V
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
J Pharm Pharmacol. 1988 Jan;40(1):74-6. doi: 10.1111/j.2042-7158.1988.tb05160.x.
Chronic desipramine (DMI) administration induced a dose-dependent reduction in the immobility time of the swim test in rats. A combined treatment of ACTH (50 iu kg-1 s.c.) and DMI (5 or 10 mg kg-1 i.p.) for 7 days potentiated the anti-immobility effect of DMI. ACTH 4-10, a fragment peptide with little corticotrophic activity, mimicked ACTH-induced potentiation. No stimulating effect on locomotor activity was observed following seven daily co-administrations of ACTH or ACTH 4-10 and DMI (10 mg kg-1). This behavioural evidence indicates that ACTH potentiation involves a central mechanism and demonstrates a functional interaction between ACTH and DMI at the behavioural level.
长期给予地昔帕明（DMI）可使大鼠在游泳试验中的不动时间呈剂量依赖性减少。促肾上腺皮质激素（ACTH，50 iu kg-1皮下注射）与DMI（5或10 mg kg-1腹腔注射）联合治疗7天可增强DMI的抗不动作用。ACTH 4-10，一种几乎没有促肾上腺皮质激素活性的片段肽，可模拟ACTH诱导的增强作用。ACTH或ACTH 4-10与DMI（10 mg kg-1）每日联合给药7天后，未观察到对运动活动的刺激作用。这一行为学证据表明，ACTH的增强作用涉及一种中枢机制，并在行为水平上证明了ACTH与DMI之间的功能相互作用。
