胺与醇或酯的脱氢偶联直接合成酰胺：锰钳形配合物作为催化剂。
Direct Synthesis of Amides by Dehydrogenative Coupling of Amines with either Alcohols or Esters: Manganese Pincer Complex as Catalyst.
机构信息
Department of Organic Chemistry, Weizmann Institute of Institution, Rehovot, 76100, Israel.
Chemical Research Support, Weizmann Institute of Science, Rehovot, 76100, Israel.
出版信息
Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14992-14996. doi: 10.1002/anie.201709180. Epub 2017 Oct 20.
PMID:28967992
Abstract
The first example of base-metal-catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom-economical and sustainable.
摘要
报告了首例通过伯胺与醇或酯的偶联反应，实现由基底金属催化合成酰胺的实例。该反应由新型锰钳形配合物催化，并生成氢气作为唯一的副产物，从而使整个过程具有原子经济性和可持续性。
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