Department of Organic Chemistry, Weizmann Institute of Institution, Rehovot, 76100, Israel.
Chemical Research Support, Weizmann Institute of Science, Rehovot, 76100, Israel.
Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14992-14996. doi: 10.1002/anie.201709180. Epub 2017 Oct 20.
The first example of base-metal-catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom-economical and sustainable.
报告了首例通过伯胺与醇或酯的偶联反应，实现由基底金属催化合成酰胺的实例。该反应由新型锰钳形配合物催化，并生成氢气作为唯一的副产物，从而使整个过程具有原子经济性和可持续性。
