儿童小脑毛细胞型星形细胞瘤：探讨手术对认知能力和功能转归的长期影响。
Cerebellar pilocytic astrocytoma in childhood: Investigating the long-term impact of surgery on cognitive performance and functional outcome.
作者信息
Pletschko Thomas, Felnhofer Anna, Lamplmair Doris, Dorfer Christian, Czech Thomas, Chocholous Monika, Slavc Irene, Leiss Ulrike
机构信息
a Department of Pediatrics and Adolescent Medicine , Medical University of Vienna , Wien , Austria.
b Department of Neurosurgery , Medical University of Vienna , Wien , Austria.
出版信息
Dev Neurorehabil. 2018 Aug;21(6):415-422. doi: 10.1080/17518423.2017.1370502. Epub 2017 Oct 2.
OBJECTIVE
Previous studies differ regarding the long-term effects of surgically removed pediatric cerebellar pilocytic astrocytomas (CPA). Thus, the aim of this study was to investigate the long-term impact on neurocognitive and functional outcome and to analyze age as an influencing factor.
METHODS
Fourteen CPA patients were compared to the age norm and to a group of 14 high-achieving peers regarding cognitive functioning, health-related quality of life (HRQoL), and stress regulation. Mean follow-up time after diagnosis was 13.29 years (range: 3-21 years).
RESULTS
Patients showed satisfactory academic achievement and did not differ from the norm except for the bodily dimension of HRQoL. However, there were marked differences in specific neurocognitive functions between patients and high achievers. Age at diagnosis did not influence neurocognitive outcome.
CONCLUSION
CPA patients treated with surgery only seem to have a favorable long-term outcome, yet, in comparison with high achievers specific cognitive impairments become apparent.
目的
以往关于手术切除小儿小脑毛细胞型星形细胞瘤（CPA）的长期影响的研究结果存在差异。因此，本研究旨在探讨其对神经认知和功能结局的长期影响，并分析年龄作为一个影响因素。
方法
将14例CPA患者在认知功能、健康相关生活质量（HRQoL）和压力调节方面与年龄正常标准以及一组14名成绩优异的同龄人进行比较。诊断后的平均随访时间为13.29年（范围：3 - 21年）。
结果
患者学业成绩令人满意，除HRQoL的身体维度外，与正常标准无差异。然而，患者与成绩优异者在特定神经认知功能方面存在显著差异。诊断时的年龄不影响神经认知结局。
结论
仅接受手术治疗的CPA患者似乎有良好的长期结局，然而，与成绩优异者相比，特定的认知障碍变得明显。
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