肿瘤坏死因子作为慢性B细胞恶性肿瘤的自分泌肿瘤生长因子。
Tumour necrosis factor as an autocrine tumour growth factor for chronic B-cell malignancies.
作者信息
Cordingley F T, Bianchi A, Hoffbrand A V, Reittie J E, Heslop H E, Vyakarnam A, Turner M, Meager A, Brenner M K
机构信息
Department of Haematology, Royal Free Hospital, London.
出版信息
Lancet. 1988 Apr 30;1(8592):969-71. doi: 10.1016/s0140-6736(88)91782-5.
Recombinant tumour necrosis factor (TNF) promotes survival and induces proliferation in the tumour cells from two malignancies of B lymphocytes--hairy-cell leukaemia and B-chronic lymphocytic leukaemia. Culture with TNF also induces TNF mRNA and protein, so the cytokine may act as an autocrine tumour growth factor. These growth promoting effects are antagonised by alpha but not by gamma interferon.
重组肿瘤坏死因子（TNF）可促进两种B淋巴细胞恶性肿瘤——毛细胞白血病和B细胞慢性淋巴细胞白血病的肿瘤细胞存活并诱导其增殖。用TNF培养也可诱导TNF信使核糖核酸（mRNA）和蛋白质的产生，因此这种细胞因子可能作为一种自分泌肿瘤生长因子发挥作用。这些促生长作用可被α干扰素而非γ干扰素拮抗。
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