Li Yuebing
Continuum (Minneap Minn). 2017 Oct;23(5, Peripheral Nerve and Motor Neuron Disorders):1378-1393. doi: 10.1212/CON.0000000000000514.
This article describes clinical features of axonal sensorimotor polyneuropathies based on selected etiologies.
Axonal sensorimotor polyneuropathies have been well described for some time. Recent advances include the assessment of the incidence of peripheral neuropathy in the elderly, the recognition of the limited influence of electrodiagnostic testing on the clinical management of uncomplicated axonal sensorimotor polyneuropathy, the development of guidelines for treatment of painful neuropathy, the identification of risk factors predisposing patients for chemotherapy-induced neuropathy, a report on the association of metabolic syndrome and idiopathic axonal sensorimotor neuropathy, and the availability of more cost-effective genetic testing for identifying inherited polyneuropathies.
Axonal sensorimotor polyneuropathies carry an extensive list of differential diagnoses. Diagnosis is based on detailed history, physical examination, recognition of associated neurologic and non-neurologic features, and appropriate testing. Disease-modifying treatments are lacking in many cases. Management focuses on modification of predisposing lifestyle and medical factors, rehabilitation, and pain relief.
本文基于特定病因描述轴索性感觉运动性多发性神经病的临床特征。
轴索性感觉运动性多发性神经病已被详细描述有一段时间了。近期进展包括对老年人周围神经病发病率的评估、认识到电诊断测试对单纯性轴索性感觉运动性多发性神经病临床管理的有限影响、制定疼痛性神经病的治疗指南、确定化疗诱导性神经病的易感危险因素、一份关于代谢综合征与特发性轴索性感觉运动性神经病关联的报告，以及有更具成本效益的基因检测可用于识别遗传性多发性神经病。
轴索性感觉运动性多发性神经病有众多鉴别诊断。诊断基于详细病史、体格检查、识别相关的神经和非神经特征以及适当的检查。许多情况下缺乏改善病情的治疗方法。管理重点在于改变易感的生活方式和医学因素、康复及缓解疼痛。
