Liu Fangteng, Dong Qing, Huang Jun
Department of General Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
Medical School of Nanchang University, Nanchang, China.
Cell Physiol Biochem. 2017;43(3):1077-1089. doi: 10.1159/000481719. Epub 2017 Oct 4.
BACKGROUND/AIMS: Many studies have reported that PVT1 played important roles in diverse cancer types. But the systematic analysis of PVT1 in gastrointestinal cancers has not been inspected. Thus, we aimed to investigate clinical value of the long noncoding RNA PVT1 (lncRNA) expression in digestive system cancers.
Eligible studies were collected from a number of databases (PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure and Wanfang database). Pooled hazard ratio (HR) or odds ratio (OR) with 95 % confidence interval (95 % Cl) were applied to assess the clinical significance of PVT1.
Data from 15 articles were included with a total of 2585 patients. Elevated PVT1 expression were significantly related to poor overall survival (OS) [HR = 1.86, 95% CI (1.44, 2.28); p<0. 0001] in digestive system cancers. The same association was also observed between PVT1 expression with outcomes, including disease free survival (DFS), disease specific survival (DSS) and relapse free survival (RFS). The lncRNA PVT1 could also be predicative for some clinicopathological features.
This meta-analysis revealed that PVT1 may serve as a prognostic predictor and pathological biomarker in digestive system cancers.
背景/目的：许多研究报道PVT1在多种癌症类型中发挥重要作用。但尚未对PVT1在胃肠道癌症中的系统分析进行研究。因此，我们旨在探讨长链非编码RNA PVT1（lncRNA）表达在消化系统癌症中的临床价值。
从多个数据库（PubMed、Web of Science、Embase、中国国家知识基础设施和万方数据库）收集符合条件的研究。采用合并风险比（HR）或比值比（OR）及95%置信区间（95%Cl）来评估PVT1的临床意义。
纳入15篇文章的数据，共2585例患者。在消化系统癌症中，PVT1表达升高与总体生存期（OS）差显著相关[HR = 1.86，95%CI（1.44，2.28）；p<0.0001]。在PVT1表达与无病生存期（DFS）、疾病特异性生存期（DSS）和无复发生存期（RFS）等预后之间也观察到相同的关联。lncRNA PVT1还可预测一些临床病理特征。
这项荟萃分析表明，PVT1可能作为消化系统癌症的预后预测指标和病理生物标志物。
