Jagtap Sunil Vitthalrao, Aher Vidhya, Gadhiya Suchi, Jagtap Swati Sunil
Professor, Department of Pathology, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra India.
Assistant Lecturer, Department of Pathology, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India.
J Clin Diagn Res. 2017 Aug;11(8):EC27-EC30. doi: 10.7860/JCDR/2017/27232.10458. Epub 2017 Aug 1.
Gestational Trophoblastic Disease (GTD) is a term used for a group of pregnancy-related tumours. These consist of various tumours and tumour like lesions characterized by proliferation of trophoblastic tissue. Amongst GTD, hydatidiform moles are the most common form. These lesions sometimes may develop into invasive moles, or, in rare cases, into choriocarcinoma.
To study the clinicopathologic characteristics and prevalence of different forms of gestational trophoblastic disease in a tertiary care hospital.
The present study was descriptive, observational, analytical type done in Department of Pathology at tertiary care hospital from May 2012 to April 2016. All cases clinically suspected of GTD were included and confirmation was done by histopathological study on H&E stained slides. The cases of GTD were classified according to WHO classification. Detailed histomorphological features and beta human Chorionic Gonadotropin (hCG) levels were correlated.
During study period, 18345 deliveries were reported; out of which 77 cases were diagnosed as GTD. Almost 97.40% cases were of hydatidiform moles, 1.30% cases of choriocarcinoma and 1.30% cases of Placental Site Trophoblastic Tumour (PSTT). Among the cases of hydatidiform mole 57.34% were complete mole and 41.33% cases were of partial mole. The common clinical presentation was per vaginal bleeding and amenorrhea. The blood group A was most commonly observed in patient (49.35%). In majority of cases beta hCG levels were between 50,000 to 100000 mIU/ml. The correlation between beta hCG level and GTD were done.
Pregnant females clinically presenting with abnormal vaginal bleeding must be evaluated for GTD. Histopathological examination is helpful for confirmatory diagnosis. Follow up of such patients is essential for early detection of malignant trophoblastic tumours.
妊娠滋养细胞疾病（GTD）是用于一组与妊娠相关肿瘤的术语。这些包括各种以滋养层组织增生为特征的肿瘤和肿瘤样病变。在GTD中，葡萄胎是最常见的形式。这些病变有时可能发展为侵袭性葡萄胎，或在罕见情况下发展为绒毛膜癌。
研究一家三级护理医院中不同形式妊娠滋养细胞疾病的临床病理特征及患病率。
本研究为描述性、观察性、分析性研究，于2012年5月至2016年4月在一家三级护理医院的病理科进行。纳入所有临床怀疑为GTD的病例，并通过苏木精-伊红（H&E）染色切片的组织病理学研究进行确诊。GTD病例根据世界卫生组织（WHO）分类进行分类。详细的组织形态学特征与β人绒毛膜促性腺激素（hCG）水平进行了相关性分析。
在研究期间，报告了18345例分娩；其中77例被诊断为GTD。几乎97.40%的病例为葡萄胎，1.30%的病例为绒毛膜癌，1.30%的病例为胎盘部位滋养细胞肿瘤（PSTT）。在葡萄胎病例中，57.34%为完全性葡萄胎，41.33%为部分性葡萄胎。常见的临床表现为阴道出血和闭经。患者中最常观察到的血型为A型（49.35%）。在大多数病例中，β-hCG水平在50,000至100,000 mIU/ml之间。进行了β-hCG水平与GTD之间的相关性分析。
临床上出现异常阴道出血的妊娠女性必须接受GTD评估。组织病理学检查有助于确诊。对这些患者进行随访对于早期发现恶性滋养细胞肿瘤至关重要。
