Herrmann Alyssa, Samelson-Jones Benjamin J, Brake Sami, Samelson Renee
Albany Medical College, Albany, New York.
The Cleveland Clinic Women's Health Institute, Cleveland, Ohio.
AJP Rep. 2017 Jul;7(3):e197-e200. doi: 10.1055/s-0037-1607055. Epub 2017 Sep 29.
Treatment for neonatal alloimmune thrombocytopenia (NAIT) primarily involves maternal administration of intravenous immunoglobulin (IVIG) therapy and prednisone according to protocols based on risk stratification. While IVIG is generally well tolerated, hematologic side effects are a potential complication. We present the successful management of a rare complication of maternal pancytopenia following standard IVIG treatment. Diagnosis was made during routine obstetric exams. Management included reducing IVIG dosage and adding daily prednisone. Additionally, infusion Lots possibly associated with the event were identified and avoided. Interventions resulted in the resolution of pancytopenia and the birth of a healthy infant without thrombocytopenia. Pancytopenia is a rare complication of IVIG treatment in women with pregnancies complicated by NAIT. Serial complete blood counts at the time of treatment would allow for early detection and timely management of the patient. Additionally, limiting the number of infusion Lots may decrease the chance of the described complications.
新生儿同种免疫性血小板减少症（NAIT）的治疗主要包括根据基于风险分层的方案，对母亲进行静脉注射免疫球蛋白（IVIG）治疗和泼尼松治疗。虽然IVIG通常耐受性良好，但血液学副作用是一种潜在的并发症。 我们介绍了一例在标准IVIG治疗后发生的罕见并发症——母亲全血细胞减少症的成功管理案例。诊断是在常规产科检查期间做出的。管理措施包括减少IVIG剂量并添加每日泼尼松。此外，识别并避免了可能与该事件相关的输液批次。干预措施导致全血细胞减少症得到缓解，并且产下了一名没有血小板减少症的健康婴儿。 全血细胞减少症是妊娠合并NAIT的女性接受IVIG治疗时罕见的并发症。治疗时进行系列全血细胞计数有助于早期发现并及时管理患者。此外，限制输液批次数量可能会降低所述并发症的发生几率。
