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数字波形技术与下一代质谱仪

Digital Waveform Technology and the Next Generation of Mass Spectrometers.

作者信息

Hoffman Nathan M, Gotlib Zachary P, Opačić Bojana, Huntley Adam P, Moon Ashley M, Donahoe Katherine E G, Brabeck Gregory F, Reilly Peter T A

机构信息

Department of Chemistry, Washington State University, Fulmer 104B, Pullman, WA, 99164-4630, USA.

出版信息

J Am Soc Mass Spectrom. 2018 Feb;29(2):331-341. doi: 10.1007/s13361-017-1807-8. Epub 2017 Oct 2.

DOI:10.1007/s13361-017-1807-8
PMID:28971335
Abstract

Ion traps and guides are integral parts of current commercial mass spectrometers. They are currently operated with sinusoidal waveform technology that has been developed over many years. Recently, digital waveform technology has begun to emerge and promises to supplant its older cousin because it presents new capabilities that result from the ability to instantaneously switch the frequency and duty cycle of the waveforms. This manuscript examines these capabilities and reveals their uses and effects on instrumentation. Graphical Abstract ᅟ.

摘要

离子阱和离子导向器是当前商用质谱仪的重要组成部分。它们目前采用的是经过多年发展的正弦波形技术。最近,数字波形技术开始出现,并有望取代其“老大哥”,因为它具有一些新功能,这些功能源于能够即时切换波形的频率和占空比。本手稿研究了这些功能,并揭示了它们在仪器中的用途和影响。图形摘要ᅟ。

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本文引用的文献

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2
Note: An inexpensive square waveform ion funnel driver.注意:一种廉价的方波离子漏斗驱动器。
Rev Sci Instrum. 2017 Jan;88(1):016104. doi: 10.1063/1.4974345.
3
Computational Analysis of Quadrupole Mass Filters Employing Nontraditional Waveforms.采用非传统波形的四极质量滤波器的计算分析。
利用红外激活结合离子/离子反应对高质量蛋白质复合物进行数字离子阱质谱分析。
Int J Mass Spectrom. 2020 Dec;458. doi: 10.1016/j.ijms.2020.116437. Epub 2020 Sep 20.
4
Ion trap operational modes for ion/ion reactions yielding high mass-to-charge product ions.用于产生高质量电荷比产物离子的离子/离子反应的离子阱操作模式。
Int J Mass Spectrom. 2020 May;451. doi: 10.1016/j.ijms.2020.116313. Epub 2020 Feb 21.
5
Increasing the Upper Mass/Charge Limit of a Quadrupole Ion Trap for Ion/Ion Reaction Product Analysis via Waveform Switching.通过波形切换提高用于离子/离子反应产物分析的四极杆离子阱的质荷比上限
J Am Soc Mass Spectrom. 2019 Jun;30(6):1126-1132. doi: 10.1007/s13361-019-02156-z. Epub 2019 Mar 14.
6
Using Digital Waveforms to Mitigate Solvent Clustering During Mass Filter Analysis of Proteins.利用数字波形缓解蛋白质质量过滤分析过程中溶剂聚结。
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J Am Soc Mass Spectrom. 2016 Jun;27(6):1122-7. doi: 10.1007/s13361-016-1358-4. Epub 2016 Apr 18.
4
Development of MS(n) in digitally operated linear ion guides.数字操作线性离子阱中MS(n)的发展
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5
Increasing the Trapping Mass Range to m/z = 10(9)-A Major Step Toward High Resolution Mass Analysis of Intact RNA, DNA and Viruses.将捕获质量范围提高到m/z = 10(9)——迈向完整RNA、DNA和病毒高分辨率质谱分析的重要一步。
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High-resolution ultra-high mass spectrometry: increasing the m/z range of protein analysis.高分辨率超高效质谱法:增加蛋白质分析的 m/z 范围。
Proteomics. 2012 Oct;12(19-20):3020-9. doi: 10.1002/pmic.201270136. Epub 2012 Aug 29.
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