University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Department of Informatics, Ionian University, Corfu, 49100, Greece.
Adv Exp Med Biol. 2017;988:301-311. doi: 10.1007/978-3-319-56246-9_25.
The rise of precision medicine combined with the variety of biomedical data sources and their heterogeneous nature make the integration and exploration of information that they retain more complicated. In light of these issues, translational research platforms were developed as a promising solution. Research centers have used translational tools for the study of integrated data for hypothesis development and validation, cohort discovery and data-exploration. For this article, we reviewed the literature in order to determine the use of translational research platforms in precision medicine. These tools are used to support scientists in various domains regarding precision medicine research. We identified eight platforms: BRISK, iCOD, iDASH, tranSMART, the recently developed OncDRS, as well as caTRIP, cBio Cancer Portal and G-DOC. The last four platforms explore multidimensional data specifically for cancer research. We focused on tranSMART, for it is the most broadly used platform, since its development in 2012.
精准医学的兴起，加上各种生物医学数据源及其异质性，使得整合和探索它们所保留的信息变得更加复杂。针对这些问题，转化研究平台应运而生，成为一种有前途的解决方案。研究中心已经使用转化工具来研究综合数据，以进行假设开发和验证、队列发现和数据探索。在本文中，我们回顾了文献，以确定转化研究平台在精准医学中的应用。这些工具用于支持各个领域的科学家进行精准医学研究。我们确定了八个平台：BRISK、iCOD、iDASH、tranSMART、最近开发的 OncDRS，以及 caTRIP、cBio Cancer Portal 和 G-DOC。后四个平台专门针对癌症研究探索多维数据。我们专注于 tranSMART，因为它是自 2012 年开发以来使用最广泛的平台。
