Weill Cornell Medicine, New York, New York, USA.
Clin Pharmacol Ther. 2018 Apr;103(4):556-557. doi: 10.1002/cpt.858. Epub 2017 Oct 3.
Diagnoses of drug-treatable illnesses has drifted to include milder conditions than in the past. Treating them increases the number of drugs given a person, risking polypharmacy, especially in elderly people with multiple conditions. The adverse consequences of polypharmacy are increased costs, confusion when taking drugs, adverse drug events, intermittent adherence with adverse drug discontinuation effects, and unrecognized delayed adverse effects. Deciding what not to treat helps minimize polypharmacy and its consequences.
诊断可通过药物治疗的疾病的标准已放宽，比过去包含了更多轻症。对这些病症进行治疗增加了患者所服用药物的种类，从而增加了药物相互作用的风险，尤其是在患有多种疾病的老年人群中。药物相互作用的不良后果包括成本增加、用药困惑、药物不良反应、药物间断性中断的不良影响以及延迟的不良反应未被识别等。决定不治疗哪些疾病有助于最大限度地减少药物相互作用及其后果。
