6-O-甲基黄芩苷元对大鼠反复脑缺血/再灌注的保护作用。

Protective effect of 6-O-methyl-scutellarein on repeated cerebral ischemia/reperfusion in rats.

作者信息

Wu Wen-Yu, Zhong Yue, Lu Yu-Ting, Sun Ying, Li Nian-Guang, Shi Zhi-Hao, Dong Ze-Xi, Gu Ting, Xue Xin, Fang Fang, Li He-Min, Tang Yu-Ping, Duan Jin-Ao

机构信息

a Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine , Nanjing University of Chinese Medicine , Nanjing 210023 , China.

b Department of Organic Chemistry , China Pharmaceutical University , Nanjing 211198 , China.

出版信息

J Asian Nat Prod Res. 2018 Dec;20(12):1167-1181. doi: 10.1080/10286020.2017.1383396. Epub 2017 Oct 3.

DOI:10.1080/10286020.2017.1383396

PMID:28971689

Abstract

Scutellarin (1) possesses protective effects against neuronal injury, while 6-O-methyl-scutellarein (3), as the main metabolite of scutellarin in vivo, has not been reported about its protective effects previously. The present study mainly investigated whether the neural injury caused by ischemia/reperfusion would be influenced by different doses of 6-O-methyl-scutellarein (3). The results of behavioral, neurological, and histological examinations indicated that 6-O-methyl-scutellarein (3) could improve neuronal injury, and exhibit significant difference among the various doses. More importantly, 6-O-methyl-scutellarein (3) had better protective effects than scutellarin in rat cerebral ischemia.

摘要

灯盏花素（1）对神经元损伤具有保护作用，而6-O-甲基灯盏花乙素（3）作为灯盏花素在体内的主要代谢产物，此前尚未见其保护作用的报道。本研究主要探讨不同剂量的6-O-甲基灯盏花乙素（3）是否会影响缺血/再灌注引起的神经损伤。行为学、神经学和组织学检查结果表明，6-O-甲基灯盏花乙素（3）可改善神经元损伤，且不同剂量之间存在显著差异。更重要的是，在大鼠脑缺血模型中，6-O-甲基灯盏花乙素（3）的保护作用优于灯盏花素。