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Br J Pharmacol. 1988 Mar;93(3):491-500. doi: 10.1111/j.1476-5381.1988.tb10303.x.
2
Rat hippocampal muscarinic autoreceptors are similar to the M2 (cardiac) subtype: comparison with hippocampal M1, atrial M2 and ileal M3 receptors.大鼠海马毒蕈碱自身受体与M2（心脏）亚型相似：与海马M1、心房M2和回肠M3受体的比较。
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Pharmacological evidence for distinct muscarinic receptor subtypes coupled to the inhibition of adenylate cyclase and to the increased generation of inositol phosphates in the guinea pig myometrium.豚鼠子宫肌层中与腺苷酸环化酶抑制及肌醇磷酸生成增加相关的不同毒蕈碱受体亚型的药理学证据。
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Antispasmodic Drug Drofenine as an Inhibitor of Kv2.1 Channel Ameliorates Peripheral Neuropathy in Diabetic Mice.抗痉挛药物曲马多作为Kv2.1通道抑制剂可改善糖尿病小鼠的周围神经病变。
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Cholinomimetic activities of minaprine.
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Rat hippocampal muscarinic autoreceptors are similar to the M2 (cardiac) subtype: comparison with hippocampal M1, atrial M2 and ileal M3 receptors.大鼠海马毒蕈碱自身受体与M2（心脏）亚型相似：与海马M1、心房M2和回肠M3受体的比较。
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本文引用的文献

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Some quantitative uses of drug antagonists.药物拮抗剂的一些定量应用。
Br J Pharmacol Chemother. 1959 Mar;14(1):48-58. doi: 10.1111/j.1476-5381.1959.tb00928.x.
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Antagonist discrimination between ganglionic and ileal muscarinic receptors.神经节与回肠毒蕈碱受体之间的拮抗剂鉴别
Br J Pharmacol. 1980;71(2):362-4. doi: 10.1111/j.1476-5381.1980.tb10948.x.
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Three types of muscarinic receptors? [proceedings].三种毒蕈碱受体？[会议论文集]
Br J Pharmacol. 1980 Jan;68(1):141P-142P.
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Pirenzepine distinguishes between different subclasses of muscarinic receptors.哌仑西平可区分毒蕈碱受体的不同亚类。
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Muscarinic receptor subtypes: M1 and M2 biochemical and functional characterization.毒蕈碱受体亚型：M1和M2的生化及功能特性
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Modification of the binding properties of muscarinic receptors by gallamine.加拉明对毒蕈碱受体结合特性的修饰作用。
Mol Pharmacol. 1983 May;23(3):551-7.
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Inositol phospholipid hydrolysis in rat cerebral cortical slices: I. Receptor characterisation.大鼠大脑皮质切片中的肌醇磷脂水解：I. 受体特性
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[3H]Rauwolscine and [3H]yohimbine binding to rat cerebral and human platelet membranes: possible heterogeneity of alpha 2-adrenoceptors.[3H]育亨宾与[3H]利血平逆结合大鼠脑和人血小板膜：α2-肾上腺素能受体可能具有异质性
Eur J Pharmacol. 1982 Oct 15;84(1-2):79-85. doi: 10.1016/0014-2999(82)90159-5.
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Ligand: a versatile computerized approach for characterization of ligand-binding systems.配体：一种用于表征配体结合系统的通用计算机化方法。
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Characterization of alpha-1 adrenergic receptors linked to [3H]inositol metabolism in rat cerebral cortex.与大鼠大脑皮层中[3H]肌醇代谢相关的α-1肾上腺素能受体的特性研究
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使用亚型选择性毒蕈碱受体拮抗剂的功能和直接结合研究。

Functional and direct binding studies using subtype selective muscarinic receptor antagonists.

作者信息

Kunysz E L, Michel A D, Whiting R L

机构信息

Department of Pharmacology, Palo Alto, CA 94304.

出版信息

Br J Pharmacol. 1988 Mar;93(3):491-500. doi: 10.1111/j.1476-5381.1988.tb10303.x.

DOI:10.1111/j.1476-5381.1988.tb10303.x
PMID:2897216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1853838/
Abstract
  1. Muscarinic receptor antagonists were examined in direct binding studies on guinea-pig cardiac and cortical muscarinic receptors. Pirenzepine, dicyclomine and hexahydroadiphenine were shown to be selective ligands for the putative M1-muscarinic receptor. 2. Functional affinity estimates of the muscarinic ligands studied was determined from their ability to inhibit carbachol-stimulated inositol phosphate (IP) accumulation in guinea-pig cortical slices. 3. The affinity estimates for the inhibition of muscarinic agonist-stimulated IP accumulation were better correlated with affinity estimates obtained from binding studies on the M1 than the M2 muscarinic receptor. 4. These data provide additional evidence, both from direct binding and functional studies, for the presence of M1 and M2 muscarinic receptor subtypes.
摘要
  1. 在豚鼠心脏和皮层毒蕈碱受体的直接结合研究中对毒蕈碱受体拮抗剂进行了检测。哌仑西平、双环维林和六氢阿地芬宁被证明是假定的M1毒蕈碱受体的选择性配体。2. 所研究的毒蕈碱配体的功能亲和力估计值是根据它们抑制豚鼠皮层切片中卡巴胆碱刺激的肌醇磷酸（IP）积累的能力来确定的。3. 抑制毒蕈碱激动剂刺激的IP积累的亲和力估计值与从M1而非M2毒蕈碱受体结合研究中获得的亲和力估计值相关性更好。4. 这些数据从直接结合和功能研究两方面为M1和M2毒蕈碱受体亚型的存在提供了额外证据。