Rougé Bugat M-E, Bourgouin M, Gérard S, Lozano S, Brechemier D, Cestac P, Cool C, Balardy L
Marie-Eve Rougé Bugat, MD PhD, DESC Oncology, 59 rue de la Providence, 31500 Toulouse, France, +33561800123, +33683058806,
J Nutr Health Aging. 2017;21(8):849-854. doi: 10.1007/s12603-017-0946-8.
Consequences of inappropriate prescriptions and polymedication in patients suffering from cancer are beginning to be well documented. However, the methods used to evaluate these consequences are often discussed. Few studies evaluate the risk of interaction with anticancer drugs in elderly patients suffering from cancer.
To describe the prevalence (i) of polypharmacy, (ii) of potentially inappropriate drug prescriptions and (iii) of drug interactions involving anticancer treatments, using a multiple reference tools.
A retrospective, cross-sectional, multicenter study performed from January to December 2012.
Patients aged 65 years or older suffering from cancer presented at the oncogeriatric multidisciplinary meeting.
Polymedication (>6 drugs), potentially inappropriate prescriptions and drug interactions involving anticancer treatment were analyzed in combination with explicit and implicit criteria within a global approach.
Among the 106 patients included in this study, polypharmacy was present in 60.4% of cases, potentially inappropriate drug prescription in 63.1% and drug interactions in 16% of case, of which 47% involved anti-cancer treatments. Twenty-seven major drug interactions were identified and eight interactions involved chemotherapy.
Polymedication, inappropriate prescribing and drug interactions involving anti-cancer drugs are common and largely underestimated in elderly cancer patients.
癌症患者不恰当处方和多种药物联合使用的后果已开始得到充分记录。然而，用于评估这些后果的方法常常受到讨论。很少有研究评估老年癌症患者中与抗癌药物相互作用的风险。
使用多种参考工具描述（i）多种药物联合使用、（ii）潜在不恰当药物处方以及（iii）涉及抗癌治疗的药物相互作用的患病率。
2012年1月至12月进行的一项回顾性、横断面、多中心研究。
65岁及以上的癌症患者参加老年肿瘤多学科会议。
在一种整体方法中，结合明确和隐含标准分析多种药物联合使用（>6种药物）、潜在不恰当处方以及涉及抗癌治疗的药物相互作用。
在本研究纳入的106例患者中，60.4%的病例存在多种药物联合使用，63.1%存在潜在不恰当药物处方，16%存在药物相互作用，其中47%涉及抗癌治疗。识别出27种主要药物相互作用，8种相互作用涉及化疗。
多种药物联合使用、不恰当处方以及涉及抗癌药物的药物相互作用在老年癌症患者中很常见，且大多被低估。
