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Lyt-2⁺细胞的抗原呈递细胞。I. 由脾脏和骨髓制备的H-2不同的Thy-1⁻Ia⁻细胞对未致敏Lyt-2⁺细胞的刺激

Antigen-presenting cells for Lyt-2+ cells. I. Stimulation of unprimed Lyt-2+ cells by H-2 different Thy-1-Ia- cells prepared from spleen and bone marrow.

作者信息

Sprent J, Schaefer M

机构信息

Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037.

出版信息

J Immunol. 1988 Jun 1;140(11):3745-50.

PMID:2897393
Abstract

In agreement with previous studies on Ia- tumor cells, evidence is presented that primary MLR of purified Lyt-2+ T cells to class I alloantigens can be elicited by a minor population of Thy 1- Ia- cells present in normal spleen, bone marrow, and day-13 fetal liver; these cells are non-stimulatory for L3T4+ T cells. The data strengthen the view that primary responses of Lyt-2+ cells do not require the presence of Ia+ cells.

摘要

与先前关于Ia-肿瘤细胞的研究一致，有证据表明，正常脾脏、骨髓和13日龄胎肝中存在的少量Thy 1-Ia-细胞可引发纯化的Lyt-2+ T细胞对I类同种异体抗原的初次混合淋巴细胞反应；这些细胞对L3T4+ T细胞无刺激作用。这些数据强化了Lyt-2+细胞的初次反应不需要Ia+细胞存在的观点。

相似文献

1
Antigen-presenting cells for Lyt-2+ cells. I. Stimulation of unprimed Lyt-2+ cells by H-2 different Thy-1-Ia- cells prepared from spleen and bone marrow.Lyt-2⁺细胞的抗原呈递细胞。I. 由脾脏和骨髓制备的H-2不同的Thy-1⁻Ia⁻细胞对未致敏Lyt-2⁺细胞的刺激
J Immunol. 1988 Jun 1;140(11):3745-50.
2
Property of class I H-2 alloantigen-reactive Lyt-2+ helper T cell subset. Abrogation of its proliferative and IL-2-producing capacities by intravenous injection of class I H-2-disparate allogeneic cells.I类H-2同种异体抗原反应性Lyt-2+辅助性T细胞亚群的特性。通过静脉注射I类H-2不同的同种异体细胞消除其增殖和产生白细胞介素-2的能力。
J Immunol. 1988 Aug 1;141(3):721-7.
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Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens.纯化T细胞亚群的特性。I. 对I类与II类H-2同种异体抗原的体外反应。
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Relationship among function, phenotype, and specificity in primary allospecific T cell populations: identification of phenotypically identical but functionally distinct primary T cell subsets that differ in their recognition of MHC class I and class II allodeterminants.原发性同种特异性T细胞群体中功能、表型和特异性之间的关系：鉴定表型相同但功能不同的原发性T细胞亚群，这些亚群在对MHC I类和II类同种异体决定簇的识别上存在差异。
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[A study of proliferative responses to host Ia antigens in fully allogeneic bone marrow chimeras in mice--sequential analysis of the reactivity and characterization of the cells involved in the response].[小鼠完全同种异体骨髓嵌合体中对宿主Ia抗原增殖反应的研究——反应性的序列分析及参与反应的细胞特性]
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Antigen-presenting T cells. I. Class I alloantigen (bm1)-bearing T lymphoblasts efficiently stimulate a primary clonal response of Lyt-2+ cytotoxic lymphocyte precursors of B6 origin.抗原呈递T细胞。I. 携带I类同种异体抗原（bm1）的T淋巴母细胞可有效刺激源自B6的Lyt-2 + 细胞毒性淋巴细胞前体的原发性克隆反应。
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引用本文的文献

1
Restricted tissue distribution of Mlsa determinants. Stimulation of Mlsa-reactive T cells by B cells but not by dendritic cells or macrophages.Mlsa决定簇的组织分布受限。B细胞可刺激Mlsa反应性T细胞，而树突状细胞或巨噬细胞则不能。
J Exp Med. 1989 Jan 1;169(1):1-12. doi: 10.1084/jem.169.1.1.