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利用 LC-ESI QTOF-MS 对远东海星 Cucumaria echinometra 的三萜糖苷代谢产物进行分析及其在不同身体部位的分布。

Metabolite Profiling of Triterpene Glycosides of the Far Eastern Sea Cucumber Eupentacta fraudatrix and Their Distribution in Various Body Components Using LC-ESI QTOF-MS.

机构信息

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 159 Prospect 100-letiya Vladivostoka, Vladivostok 690022, Russia.

A.V. Zhirmunsky Institute of Marine Biology, National Scientific Center of Marine Biology, Far Eastern Branch of the Russian Academy of Sciences, 17 Palchevskogo St., Vladivostok 690041, Russia.

出版信息

Mar Drugs. 2017 Oct 2;15(10):302. doi: 10.3390/md15100302.

DOI:10.3390/md15100302
PMID:28974049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5666410/
Abstract

The Far Eastern sea cucumber is an inhabitant of shallow waters of the south part of the Sea of Japan. This animal is an interesting and rich source of triterpene glycosides with unique chemical structures and various biological activities. The objective of this study was to investigate composition and distribution in various body components of triterpene glycosides of the sea cucumber . We applied LC-ESI MS (liquid chromatography-electrospray mass spectrometry) of whole body extract and extracts of various body components for metabolic profiling and structure elucidation of triterpene glycosides from the . Totally, 54 compounds, including 26 sulfated, 18 non-sulfated and 10 disulfated glycosides were detected and described. Triterpene glycosides from the body walls, gonads, aquapharyngeal bulbs, guts and respiratory trees were extracted separately and the distributions of the detected compounds in various body components were analyzed. Series of new glycosides with unusual structural features were described in , which allow clarifying the biosynthesis of these compounds. Comparison of the triterpene glycosides contents from the five different body components revealed that the profiles of triterpene glycosides were qualitatively similar, and only some quantitative variabilities for minor compounds were observed.

摘要

海参是日本海南部浅海的栖息动物。这种动物是三萜糖苷类化合物的有趣且丰富的来源，具有独特的化学结构和多种生物活性。本研究的目的是研究海参中三萜糖苷类化合物的组成和分布在各种身体成分中。我们应用 LC-ESI MS（液相色谱-电喷雾质谱）对整个身体提取物和各种身体成分提取物进行代谢谱分析和结构阐明。总共检测并描述了 54 种化合物，包括 26 种硫酸化、18 种非硫酸化和 10 种二硫酸化糖苷。分别提取了海参壁、性腺、水腔球、肠道和呼吸树中的三萜糖苷类化合物，并分析了在各种身体成分中检测到的化合物的分布。描述了海参中一系列具有不寻常结构特征的新糖苷，这有助于阐明这些化合物的生物合成。比较五个不同身体成分中的三萜糖苷含量表明，三萜糖苷的图谱在质量上相似，仅观察到少数化合物的微量变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93b/5666410/e308f735bb4d/marinedrugs-15-00302-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93b/5666410/dc4e72617e69/marinedrugs-15-00302-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93b/5666410/78325a85efc2/marinedrugs-15-00302-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93b/5666410/c1a20970ad60/marinedrugs-15-00302-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93b/5666410/c819f21df468/marinedrugs-15-00302-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93b/5666410/e308f735bb4d/marinedrugs-15-00302-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93b/5666410/dc4e72617e69/marinedrugs-15-00302-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93b/5666410/78325a85efc2/marinedrugs-15-00302-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93b/5666410/c1a20970ad60/marinedrugs-15-00302-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93b/5666410/c819f21df468/marinedrugs-15-00302-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93b/5666410/e308f735bb4d/marinedrugs-15-00302-g005.jpg

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