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神经内分泌肿瘤的分子放射性诊断与治疗。

Molecular radiotheranostics for neuroendocrine tumours.

机构信息

Royal Free London NHS Foundation Trust, London, UK

Royal Marsden Hospital & Institute of Cancer Research, London, UK.

出版信息

Clin Med (Lond). 2017 Oct;17(5):462-468. doi: 10.7861/clinmedicine.17-5-462.

DOI:10.7861/clinmedicine.17-5-462
PMID:28974600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6301943/
Abstract

This article discusses the important role of nuclear medicine imaging and therapy in the management of neuroendocrine tumours (NETs). Somatostatin receptor scintigraphy has a high impact on patient management versus conventional imaging. Molecular radiotherapy is an important part of the management of patients with NETs. Selection of patients for molecular radiotherapy in NETs is based on uptake on their radionuclide imaging study. The imaging agent has the same mechanism of uptake as the therapeutic agent. Thus, the imaging study preselects patients that are likely to concentrate radiation within their tumours.

摘要

本文讨论了核医学成像和治疗在神经内分泌肿瘤(NETs)管理中的重要作用。生长抑素受体闪烁显像对患者管理的影响明显高于常规成像。分子放疗是 NETs 患者管理的重要组成部分。NETs 患者进行分子放疗的选择基于其放射性核素成像研究的摄取。成像剂与治疗剂具有相同的摄取机制。因此,成像研究预先选择了那些可能在肿瘤内集中辐射的患者。

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本文引用的文献

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Early efficacy of and toxicity from lutetium-177-DOTATATE treatment in patients with progressive metastatic NET.镥-177-奥曲肽治疗进展期转移性神经内分泌肿瘤患者的早期疗效及毒性
Nucl Med Commun. 2017 Jul;38(7):593-600. doi: 10.1097/MNM.0000000000000685.
2
Phase 3 Trial of Lu-Dotatate for Midgut Neuroendocrine Tumors.镥[177Lu]奥曲肽治疗中肠神经内分泌肿瘤的3期试验
N Engl J Med. 2017 Jan 12;376(2):125-135. doi: 10.1056/NEJMoa1607427.
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Dose response of pancreatic neuroendocrine tumors treated with peptide receptor radionuclide therapy using 177Lu-DOTATATE.使用¹⁷⁷Lu-DOTATATE的肽受体放射性核素治疗对胰腺神经内分泌肿瘤的剂量反应。
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4
Somatostatin receptor PET/CT in neuroendocrine tumours: update on systematic review and meta-analysis.生长抑素受体 PET/CT 在神经内分泌肿瘤中的应用:系统评价和荟萃分析的更新。
Eur J Nucl Med Mol Imaging. 2013 Oct;40(11):1770-80. doi: 10.1007/s00259-013-2482-z. Epub 2013 Jul 20.
5
Role of 18FDG PET/CT in patients treated with 177Lu-DOTATATE for advanced differentiated neuroendocrine tumours.18FDG PET/CT 在接受 177Lu-DOTATATE 治疗的晚期分化型神经内分泌肿瘤患者中的作用。
Eur J Nucl Med Mol Imaging. 2013 Jun;40(6):881-8. doi: 10.1007/s00259-013-2369-z. Epub 2013 Feb 27.
6
The joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours.国际原子能机构、欧洲核医学协会和核医学分子影像学会联合发布的神经内分泌肿瘤肽受体放射性核素治疗实践指南。
Eur J Nucl Med Mol Imaging. 2013 May;40(5):800-16. doi: 10.1007/s00259-012-2330-6.
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Peptides and receptors in image-guided therapy: theranostics for neuroendocrine neoplasms.在影像引导治疗中的肽和受体:神经内分泌肿瘤的治疗诊断学。
Semin Nucl Med. 2012 May;42(3):190-207. doi: 10.1053/j.semnuclmed.2012.01.002.
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J Clin Oncol. 2011 Jun 10;29(17):2416-23. doi: 10.1200/JCO.2010.33.7873. Epub 2011 May 9.