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无精子症患者手术取精程序中预后因素及决定因素的评估

Evaluation of Prognostic Factors and Determinants in Surgical Sperm Retrieval Procedures in Azoospermic Patients.

作者信息

Spahovic Hajrudin, Göktolga Ümit, Junuzovic Dzelaludin, Göktaş Cihan, Rama Admir

机构信息

Urology Clinic, University Clinical Centre of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Bahçeci BIH IVF Center, Sarajevo, Bosnia and Herzegovina.

出版信息

Med Arch. 2017 Aug;71(4):243-245. doi: 10.5455/medarh.2017.71.243-245.

DOI:10.5455/medarh.2017.71.243-245
PMID:28974842
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5585793/
Abstract

INTRODUCTION

Main categorisation of azospermic is in two grups: nonobstructive azoospermia (NOA) and obstructive azoospermia (OA). We had evaluation of prognostic factors and determinants in sperm retrieval procedures in azoospermic patients.

METHODS

Retrospective evaluation observed 21 selected patients with NOA and OA azoospermia, after that complete history, physical examination with ultarsound volume of testis and hormonal profile. Hormonal profile included: follicle stimulating hormone (FSH), luteinizing hormone (LH), testosteron (T) and prolactin (P) serum levels. Also karyotype and Y-deletion analysis were done and analyzed.

RESULTS

9 OA patients (42,9%) were undergone for TESE operation and 12 NOA patients (57,1%) for Micro-TESE operation. All TESE procedures were positive (100%). Micro-TESE in 12 selected NOA patients, 5 patients (41,6%) were positive and 7 patients (58,4%) negative. Patients testicular size, serum FSH and testosterone level showed correlation in success of sperm retrieval procedures.

CONCLUSION

TESE is elected procedure for obstructive azospermia (OA). Micro-TESE is appropriate sperm retrieval procedurec for patients with non-obstructive azoospermia (NOA) and correlate with high FSH and small volume of testis.

摘要

引言

无精子症主要分为两类：非梗阻性无精子症（NOA）和梗阻性无精子症（OA）。我们对无精子症患者精子获取程序中的预后因素和决定因素进行了评估。

方法

回顾性评估观察了21例选定的NOA和OA无精子症患者，之后进行完整病史、睾丸超声检查及激素水平检查。激素水平检查包括：血清促卵泡生成素（FSH）、促黄体生成素（LH）、睾酮（T）和催乳素（P）水平。同时进行了核型和Y染色体微缺失分析并进行了分析。

结果

9例OA患者（42.9%）接受了睾丸切开取精术（TESE），12例NOA患者（57.1%）接受了显微睾丸切开取精术（Micro-TESE）。所有TESE手术均成功（100%）。在12例选定的NOA患者中进行的Micro-TESE，5例患者（41.6%）成功，7例患者（58.4%）失败。患者的睾丸大小、血清FSH和睾酮水平与精子获取程序的成功与否相关。

结论

TESE是梗阻性无精子症（OA）的首选手术。Micro-TESE是适合非梗阻性无精子症（NOA）患者的精子获取程序，且与高FSH水平和小睾丸体积相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b656/5585793/c11cbe2a8371/MA-71-243-g008.jpg
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