α9β1整合素及其配体在自身免疫性疾病发展中的作用。
The role of α9β1 integrin and its ligands in the development of autoimmune diseases.
作者信息
Kon Shigeyuki, Uede Toshimitsu
机构信息
Department of Molecular Immunology, Faculty of Pharmaceutical Sciences, Fukuyama University, 985-1 Azasanzo, Higashimura-machi, Fukuyama, Hiroshima, 729-0292, Japan.
Division of Molecular Neuro-Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, 060-0815, Japan.
出版信息
J Cell Commun Signal. 2018 Mar;12(1):333-342. doi: 10.1007/s12079-017-0413-7. Epub 2017 Oct 3.
Abstract
Adhesion of cells to extracellular matrix proteins through integrins expressed on the cell surface is important for cell adhesion/motility, survival, and differentiation. Recently, α9β1 integrin was reported to be important for the development of autoimmune diseases including rheumatoid arthritis, multiple sclerosis, and their murine models. In addition, ligands for α9β1 integrin, such as osteopontin and tenascin-C, are well established as key regulators of autoimmune diseases. Therefore, this review focused on the role of interactions between α9β1 integrin and its ligands in the development of autoimmune diseases.
摘要
细胞通过细胞表面表达的整合素与细胞外基质蛋白的黏附对于细胞黏附/运动、存活和分化至关重要。最近，据报道α9β1整合素对于包括类风湿性关节炎、多发性硬化症及其小鼠模型在内的自身免疫性疾病的发展很重要。此外，α9β1整合素的配体，如骨桥蛋白和腱生蛋白-C，已被确认为自身免疫性疾病的关键调节因子。因此，本综述聚焦于α9β1整合素与其配体之间的相互作用在自身免疫性疾病发展中的作用。
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