School of Medicine, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Division of Internal Medicine, Santa Casa de Misericórdia de Juiz de Fora, Juiz de Fora, Brazil.
J Am Geriatr Soc. 2018 Feb;66(2):383-388. doi: 10.1111/jgs.15138. Epub 2017 Oct 4.
To evaluate the prevalence and number of potentially inappropriate medications (PIMs) in hospitalized older adults, comparing prescription patterns of medical specialties.
Retrospective cohort study.
Tertiary general hospital.
All older adults hospitalized from January through May 2015 (N = 1,900).
Information on medications prescribed during the first and last days of hospitalization was collected and evaluated regarding PIMs using Beers and Screening Tool of Older People's Prescriptions (STOPP) criteria. Medical specialties (internal medicine, cardiology, gastroenterology, infectious disease, nephrology, neurology, pneumology) were compared regarding the prevalence of PIMs and the increase in the number of PIMs during hospitalization.
The number of individuals with PIMs increased significantly according to both criteria (62.3% to 66.6% according to Beers criteria, 43.4% to 50.0% according to STOPP criteria). The most common PIMs were sliding-scale insulin (26.9%), clonazepam (9.5%), and periciazine (6.4%) using Beers criteria and spironolactone (10.3%), acetylsalicylic acid (9.8%), and periciazine (8.7%) using STOPP criteria. Neurology, infectious disease, and pneumology had the highest numbers of PIMs, and neurology, pneumology, and cardiology had a greater increase in PIMs during hospitalization than the other specialties.
This study demonstrates the high and growing prevalence of PIMs in the hospital environment, according to Beers and STOPP criteria. Educational measures and specific pharmaceutical interventions for each specialty are needed to change this situation.
评估住院老年患者潜在不适当药物(PIMs)的流行率和数量,并比较不同医学专业的处方模式。
回顾性队列研究。
三级综合医院。
2015 年 1 月至 5 月期间住院的所有老年患者(N=1900)。
收集患者在住院第 1 天和最后 1 天所开药物的信息,并使用 Beers 和 Screening Tool of Older People's Prescriptions(STOPP)标准评估 PIMs。比较不同医学专业(内科、心脏病学、胃肠病学、传染病学、肾病学、神经病学、肺病学)的 PIM 流行率和住院期间 PIM 数量的增加情况。
根据 Beers 和 STOPP 标准,PIM 患者的数量均显著增加(从 62.3%增加到 66.6%和从 43.4%增加到 50.0%)。最常见的 PIMs 包括根据 Beers 标准的胰岛素(26.9%)、氯硝西泮(9.5%)和奋乃静(6.4%),根据 STOPP 标准的螺内酯(10.3%)、乙酰水杨酸(9.8%)和奋乃静(8.7%)。神经病学、传染病学和肺病学的 PIM 数量最多,神经病学、肺病学和心脏病学在住院期间 PIM 数量的增加幅度大于其他专业。
本研究表明,根据 Beers 和 STOPP 标准,住院环境中 PIM 的流行率高且呈上升趋势。需要针对每个专业采取教育措施和特定的药物干预措施来改变这种情况。