住院老年多病患者院内药物精简对潜在药物遗漏处方的影响。
The effects of in-hospital deprescribing on potential prescribing omission in hospitalized elderly patients with polypharmacy.
机构信息
Department of Pharmacy, National Hospital Organization Tochigi Medical Center, 1-10-37, Nakatomatsuri, Utsunomiya, Tochigi, Japan.
Department of Internal Medicine, National Hospital Organization Tochigi Medical Center, 1-10-37, Nakatomatsuri, Utsunomiya, Tochigi, Japan.
出版信息
Sci Rep. 2021 Apr 26;11(1):8898. doi: 10.1038/s41598-021-88362-w.
No studies to investigate the effect of a deprescribing intervention on the occurrence of potential prescribing omissions (PPOs) among elderly patients with polypharmacy have been conducted. Therefore, the effect of deprescribing on PPOs among elderly patients with polypharmacy was investigated. All 121 consecutive elderly patients who received in-hospital deprescribing interventions were evaluated. The primary outcome was any occurrence of PPOs based on the 2015 STOPP/START criteria. The proportion of patients who had any PPOs significantly increased after the deprescribing interventions (52.9% vs 77.7%, p < 0.001). In the multivariable analysis, older age was the only independent risk factor associated with an increased risk of any PPOs after the deprescribing interventions (OR 1.08, 95% CI 1.01 to 1.16). In-hospital deprescribing interventions for elderly patients with polypharmacy may increase the occurrence of PPOs. Further study is warranted to investigate the effects on clinical outcomes of the increased occurrence of PPOs due to the deprescribing intervention.
尚未有研究调查药物减量干预对多药治疗老年患者潜在用药差错（PPO）发生的影响。因此，本研究旨在调查药物减量对多药治疗老年患者 PPO 的影响。对所有 121 例接受住院药物减量干预的老年患者进行评估。主要结局指标为根据 2015 年 STOPP/START 标准发生任何 PPO。药物减量干预后，发生任何 PPO 的患者比例显著增加（52.9% vs 77.7%，p < 0.001）。多变量分析显示，药物减量干预后，年龄较大是发生任何 PPO 的唯一独立危险因素（OR 1.08，95%CI 1.01-1.16）。对于多药治疗的老年患者，住院药物减量干预可能会增加 PPO 的发生。需要进一步研究以调查由于药物减量干预导致 PPO 发生率增加对临床结局的影响。
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